Results 71 to 80 of about 1,960 (180)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Neuropilin Is a Semaphorin III Receptor [PDF]

Cell, 1997
The semaphorin family contains a large number of phylogenetically conserved proteins and includes several members that have been shown to function in repulsive axon guidance. Semaphorin III (Sema III) is a secreted protein that in vitro causes neuronal growth cone collapse and chemorepulsion of neurites, and in vivo is required for correct sensory ...
Kolodkin, Alex L, Levengood, Dorothy V, Rowe, Erica G, Tai, Yu-Tzu, Giger, Roman J, Ginty, David D   +5 more
openaire   +2 more sources

Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?

Frontiers in Oncology, 2020
Cellular functions are regulated by extracellular signals such as hormones, neurotransmitters, matrix ligands, and other chemical or physical stimuli.
Camille Albrecht, Camille Albrecht, Aline Appert-Collin, Aline Appert-Collin, Dominique Bagnard, Dominique Bagnard, Sébastien Blaise, Sébastien Blaise, Béatrice Romier-Crouzet, Béatrice Romier-Crouzet, Roman G. Efremov, Roman G. Efremov, Hervé Sartelet, Hervé Sartelet, Laurent Duca, Laurent Duca, Pascal Maurice, Pascal Maurice, Amar Bennasroune, Amar Bennasroune   +19 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Immunohistochemical distribution of Plexin A4 in the adult rat central nervous system

Frontiers in Neuroanatomy, 2010
PlexinA4 is the latest member to be identified of the plexin A subfamily, critical transducers of class 3 semaphorin signaling as co-receptors to neuropilins 1 and 2.
Claire-Anne Gutekunst, Eric N Stewart, Robert E Gross   +2 more
doaj   +1 more source

Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang, Jing Fei, Rangrang Fan, Haifeng Chen, Liangxue Zhou, Gang Guo   +5 more
wiley   +1 more source

Neuropilins: expression and roles in the epithelium

International Journal of Experimental Pathology, 2012
SummaryInitially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis.
Jonathan R L, Wild, Carolyn A, Staton, Keith, Chapple, Bernard M, Corfe   +3 more
openaire   +3 more sources

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

The reception and the party after: how vascular endothelial growth factor receptor 2 explores cytoplasmic space

Swiss Medical Weekly, 2011
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of the type V receptor tyrosine kinases VEGFR-1, -2 and -3.
P Berger, K Ballmer-Hofer
doaj   +1 more source

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source