Results 51 to 60 of about 2,294 (205)
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
eLife, 2020 Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes ...
Natalia Zamorano Cuervo +1 more
doaj +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Neuropilins in the Context of Tumor Vasculature [PDF]
International Journal of Molecular Sciences, 2019 Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors originally identified by the binding of semaphorin and vascular endothelial growth factor. Having no cytosolic protein kinase domain, they function predominantly as co-receptors of other receptors for various ligands.
Stephan Niland, Johannes A. Eble
openaire +2 more sources
Role of Neuropilins in Zebrafish Heart Regeneration [PDF]
, 2017 BACKGROUND: Unlike adult mammals, zebrafish can regenerate their heart. Several mechanisms are essential to achieve regeneration; these include: • the de-differentiation and proliferation of cardiomyocytes contributing to new myocardium, • angiogenesis ...
Lowe, VJ
core
Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla [PDF]
, 2018 The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response.
Lumb, R. +15 more
core +1 more source
, 2023 Pancreatic cancer is a major cause of demise worldwide. Although key associated genetic changes have been discovered, disease progression is sustained by pathogenic mechanisms that are poorly understood at the molecular level.
Luca Tamagnone
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava +8 more
wiley +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
The Role of Rho GTPases in VEGF Signaling in Cancer Cells
Analytical Cellular Pathology, 2020 Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream
Nada El Baba +5 more
doaj +1 more source
Perturbation of semaphorin and VEGF signaling in ACDMPV lungs due to FOXF1 deficiency
Respiratory Research, 2021 Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal congenital lung disorder in neonates characterized by severe progressive respiratory failure and refractory pulmonary hypertension, resulting from ...
Justyna A. Karolak +6 more
doaj +1 more source