Results 31 to 40 of about 2,294 (205)
Bevacizumab resistance in breast cancer: are neuropilins the key? [PDF]
, 2008 During breast cancer growth and development, angiogenesis is triggered by the interaction between vascular endothelial growth factor (VEGF) and its receptors VEGF-R1 and VEGF-R2. In breast cancer, alternative VEGF receptors, the neuropilins (Np1 and Np2),
Brown, N.J. +7 more
core +1 more source
Neuropilins Controlling Cancer Therapy Responsiveness
, 2019 Neuropilins (NRPs) are cell surface glycoproteins, acting as co-receptors for secreted Semaphorins (SEMAs) and for members of the vascular endothelial growth factor (VEGF) family; they have been initially implicated in axon guidance and angiogenesis ...
Tamagnone L.
core +2 more sources
Metabolic Stress Induces the Lysosomal Degradation of Neuropilin-1 but Not Neuropilin-2 [PDF]
Journal of Biological Chemistry, 2008 The neuropilins-1 and -2 (NRP1 and NRP2) function as receptors for both the semaphorins and vascular endothelial growth factor. In addition to their contribution to the development of the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor progression. Given their importance to cancer and endothelial biology and their potential
Bae, Donggoo +3 more
openaire +3 more sources
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
Mechanisms of Development, 2001 Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael +4 more
openaire +2 more sources
Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development. [PDF]
, 2006 BACKGROUND: Plexins are a family of transmembrane proteins that were shown to act as receptors for Semaphorins either alone or in a complex together with Neuropilins.
Stoeckli, E T; https://orcid.org/ +9 more
core +1 more source
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Chinese Medical Journal, 2021 . Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells
Shao-Dan Liu +4 more
doaj +1 more source
A perspective on the role of class III semaphorin signaling in central nervous system trauma
Frontiers in Cellular Neuroscience, 2014 Traumatic injury of the central nervous system (CNS) has severe impact on the patients’ quality of life and initiates many molecular and cellular changes at the site of insult.
Vasil eMecollari +3 more
doaj +1 more source
Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
doaj +1 more source
World Journal of Gastroenterology, 2015 Neuropilins (NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
openaire +2 more sources
Neuropilins as signaling hubs, controlling tyrosine kinases and other cell surface receptors
, 2017 Neuropilin-1 and neuropilin-2 form a small family of transmembrane molecules found in vertebrates. In addition to their established function as cell surface co-receptors for semaphorins and vascular endothelial growth factors (VEGFs), in association with
Tamagnone L.
core +1 more source