Results 21 to 30 of about 1,960 (180)

Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility

Frontiers in Pediatrics, 2021
The neuropilins NRP1 and NRP2 are multifunctional glycoproteins that have been implicated in several cancer-related processes including cell survival, migration, and invasion in various tumor types.
Katja Eloranta, Ruth Nousiainen, Stefano Cairo, Stefano Cairo, Mikko P. Pakarinen, David B. Wilson, David B. Wilson, Marjut Pihlajoki, Markku Heikinheimo, Markku Heikinheimo   +9 more
doaj   +1 more source

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

eLife, 2023
Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration of basal dendrites ...
Eleftheria Koropouli, Qiang Wang, Rebeca Mejías, Randal Hand, Tao Wang, David D Ginty, Alex L Kolodkin   +6 more
doaj   +1 more source

Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors

Frontiers in Oncology, 2021
Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations.
Manon Douyère, Pascal Chastagner, Pascal Chastagner, Cédric Boura   +3 more
doaj   +1 more source

Vascular Endothelial Growth Factor Signaling in Models of Oxygen-Induced Retinopathy: Insights Into Mechanisms of Pathology in Retinopathy of Prematurity

Frontiers in Pediatrics, 2021
Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Semaphorin-3E/plexinD1 axis in allergic asthma

Advances in Biomedical and Health Sciences, 2022
Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi, Amena Aktar, Lianyu Shan, Latifa Koussih, Abdelilah S Gounni   +4 more
doaj   +1 more source

Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?

Frontiers in Immunology, 2020
The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu, Ewa Wojcikiewicz, Alexandra Urdaneta   +2 more
doaj   +1 more source

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity

eLife, 2022
Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey, Tyler M Hoard, Xiao-Feng Zhao, Nicole E Franks, Zoë C Frank, Alexandra N McMellen, Roman J Giger, Benjamin L Allen   +7 more
doaj   +1 more source

The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation

Frontiers in Immunology, 2021
Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth, Salina Gairhe, Parizad Torabi-Parizi   +2 more
doaj   +1 more source

Les neuropilines [PDF]

médecine/sciences, 2020
Une angiogenèse exacerbée est une des caractéristiques («hallmarks») du cancer, définies par Hanahan et Weinberg1. Cependant, le ciblage de la voie de signalisation du VEGF (vascular endothelial growth factor) ou de ses récepteurs a montré ses limites thérapeutiques.
Dumond, Aurore, Demange, Luc, Pagès, Gilles   +2 more
openaire   +1 more source