Results 21 to 30 of about 2,294 (205)
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
doaj +1 more source
Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
doaj +1 more source
médecine/sciences, 2020 Une angiogenèse exacerbée est une des caractéristiques («hallmarks») du cancer, définies par Hanahan et Weinberg1. Cependant, le ciblage de la voie de signalisation du VEGF (vascular endothelial growth factor) ou de ses récepteurs a montré ses limites thérapeutiques.
Dumond, Aurore +2 more
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Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
doaj +1 more source
Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis [PDF]
Cancer Research Communications, 2022 Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as to whether NRP1 and NRP2 act in a
Christopher J. Benwell +4 more
openaire +3 more sources
eLife, 2015 Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and ...
Xuecai Ge +7 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond +14 more
doaj +1 more source
Neuropilins, as Relevant Oncology Target: Their Role in the Tumoral Microenvironment
Frontiers in Cell and Developmental Biology, 2020 Angiogenesis is one of the key mechanisms involved in tumor growth and metastatic dissemination. The vascular endothelial growth factor (VEGF) and its receptors (VEGFR) represent one of the major signaling pathways which mediates angiogenesis.
Aurore Dumond +2 more
doaj +1 more source
Neuropilins: C-end rule peptides and their association with nociception and COVID-19
Computational and Structural Biotechnology Journal, 2021 Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2).
Amie Jobe, Ranjit Vijayan
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SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
doaj +1 more source