In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer [PDF]
Frontiers in Chemistry, 2023 Introduction: Breast cancer poses a significant global challenge, prompting researchers to explore novel approaches for potential treatments.Material and Methods: For in vitro study we used thin layer chromatography (TAC) for phytochemical screening ...
Abdel-Rhman Z Gaafar +2 more
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VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins [PDF]
Biomolecules, 2022 Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels’ formation and function. Each of the proteins from the homologous family VEGFA, VEGFB, VEGFC and VEGFD employs a core cysteine-knot structural domain for ...
Charles Eldrid +7 more
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Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
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Neuropilins as potential biomarkers in hepatocellular carcinoma: a systematic review of basic and clinical implications [PDF]
Clinical and Molecular Hepatology, 2023 Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide and is characterized by complex molecular carcinogenesis. Neuropilins (NRPs) NRP1 and NRP2 are the receptors of multiple proteins involved in key signaling pathways ...
Paula Fernández-Palanca +6 more
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The Significance of Neuropilins in Gastrointestinal Cancers. [PDF]
Int J Mol SciCancers represent a significant global health concern, being among the most prevalent malignancies and contributing substantially to morbidity and mortality rates. Notably, colorectal, gastric, pancreatic, and liver cancers are the most frequently diagnosed among these malignancies.
Królikowska K +5 more
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Cells, 2019 There is emerging evidence that molecules, receptors, and signaling mechanisms involved in vascular development also play crucial roles during the development of the nervous system.
JOSÉ Antonio Del Rio +2 more
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Neuropilins, as Relevant Oncology Target: Their Role in the Tumoral Microenvironment
Frontiers in Cell and Developmental Biology, 2020 Angiogenesis is one of the key mechanisms involved in tumor growth and metastatic dissemination. The vascular endothelial growth factor (VEGF) and its receptors (VEGFR) represent one of the major signaling pathways which mediates angiogenesis.
Gilles Pages +2 more
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Neuropilin-1: A Multifaceted Target for Cancer Therapy [PDF]
Current OncologyNeuropilin-1 (NRP1), initially identified as a neuronal guidance protein, has emerged as a multifaceted regulator in cancer biology. Beyond its role in axonal guidance and angiogenesis, NRP1 is increasingly recognized for its significant impact on tumor ...
Sai Manasa Varanasi +4 more
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Semaphorins: from CD8⁺ T cells to cancer immunotherapy [PDF]
Biomarker ResearchSemaphorins were initially identified as axon guidance molecules in the nervous system, where they transmit repulsive signals to restrict axonal growth by regulating the dynamics of growth cone cytoskeletal structures.
Zhiying Liu +5 more
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Immune Checkpoint Neuropilins as Novel Biomarkers and Therapeutic Targets for Pancreatic Cancer [PDF]
Cancers, 2023 Xueli Bai, He Li-Hong
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