Results 11 to 20 of about 2,294 (205)
The Significance of Neuropilins in Gastrointestinal Cancers. [PDF]
Int J Mol SciCancers represent a significant global health concern, being among the most prevalent malignancies and contributing substantially to morbidity and mortality rates. Notably, colorectal, gastric, pancreatic, and liver cancers are the most frequently diagnosed among these malignancies.
Królikowska K +5 more
europepmc +5 more sources
Multifaceted Role of Neuropilins in Cancer
Current Medicinal Chemistry, 2011 Neuropilins comprise two homologous widely-expressed single-pass plasma membrane receptors (Nrp1 and Nrp2), originally identified for binding secreted Semaphorins and Vascular Endothelial Growth Factors (in association with Plexins and VEGF-Receptors).
Rizzolio, S., Tamagnone, L.
openaire +4 more sources
Specific Neuropilins Expression in Alveolar Macrophages among Tissue-Specific Macrophages. [PDF]
PLoS ONE, 2016 In the immune system, neuropilins (NRPs), including NRP-1 and NRP-2, are expressed in thymocytes, dendritic cells, regulatory T cells and macrophages.
Naing Ye Aung +6 more
doaj +2 more sources
Cell Adhesion & Migration, 2007 It is now well established that neuropilins (NRP1 and NRP2), first described as mediators of neuronal guidance, are also mediators of angiogenesis and tumor progression. NRPs are receptors for the class-3 semaphorin (SEMA) family of axon guidance molecules and also for the vascular endothelial growth factor (VEGF) family of angiogenic factors. VEGF-NRP
Elena, Geretti, Michael, Klagsbrun
openaire +3 more sources
A role for neuropilins in the interaction between Schwann cells and meningeal cells. [PDF]
PLoS ONE, 2014 In their natural habitat, the peripheral nerve, Schwann cells (SCs) form nicely aligned pathways (also known as the bands of Büngner) that guide regenerating axons to their targets.
Kasper C D Roet +3 more
doaj +2 more sources
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy [PDF]
Frontiers in Immunology, 2017 Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 (NRP1) and neuropilin-2 (NRP2), mainly act as coreceptors for class III ...
Sohini Roy +5 more
doaj +2 more sources
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors
Frontiers in Oncology, 2021 Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations.
Manon Douyère +3 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj +1 more source
Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source