Results 41 to 50 of about 1,960 (180)
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Chinese Medical Journal, 2021 . Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells
Shao-Dan Liu +4 more
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Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
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Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
Mechanisms of Development, 2001 Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael +4 more
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Metabolic Stress Induces the Lysosomal Degradation of Neuropilin-1 but Not Neuropilin-2 [PDF]
Journal of Biological Chemistry, 2008 The neuropilins-1 and -2 (NRP1 and NRP2) function as receptors for both the semaphorins and vascular endothelial growth factor. In addition to their contribution to the development of the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor progression. Given their importance to cancer and endothelial biology and their potential
Bae, Donggoo +3 more
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Frontiers in Cell and Developmental Biology, 2020 Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over the extracellular matrix via integrin receptors to respond to an angiogenic stimulus.
Abdullah A. A. Alghamdi +6 more
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Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. [PDF]
PLoS ONE, 2014 Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role
Daniella Arêas Mendes-da-Cruz +20 more
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World Journal of Gastroenterology, 2015 Neuropilins (NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
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Semaphorins and Their Receptors: From Axonal Guidance to Atherosclerosis
Frontiers in Physiology, 2018 Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins initially identified as axon guidance cues signaling through their receptors, neuropilins, and plexins.
Shuhong Hu, Shuhong Hu, Li Zhu, Li Zhu
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Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
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Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway. [PDF]
PLoS ONE, 2013 Class 3 semaphorins are well-known axonal guidance cues during the embryonic development of mammalian nervous system. However, their activity on postnatally differentiated neurons in neurogenic regions of adult brains has not been characterized. We found
Teclise Ng +6 more
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