Results 41 to 50 of about 2,294 (205)
Neuropilins: Role in Signalling, Angiogenesis and Disease [PDF]
, 2013 Neuropilins (NRPs) are co-receptors for class 3 semaphorins and for members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines.
Ian Zachary, Zachary, I
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over the extracellular matrix via integrin receptors to respond to an angiogenic stimulus.
Abdullah A. A. Alghamdi +6 more
doaj +1 more source
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. [PDF]
PLoS ONE, 2014 Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role
Daniella Arêas Mendes-da-Cruz +20 more
doaj +1 more source
Neuropilin-1 in Transplantation Tolerance [PDF]
Frontiers in Immunology, 2013 In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that seems to distinguish natural T regulatory (nTreg) cells, generated in the thymus, from inducible T regulatory (iTreg) cells raised ...
Campos Mora, Mauricio +4 more
openaire +4 more sources
Semaphorins and Their Receptors: From Axonal Guidance to Atherosclerosis
Frontiers in Physiology, 2018 Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins initially identified as axon guidance cues signaling through their receptors, neuropilins, and plexins.
Shuhong Hu, Shuhong Hu, Li Zhu, Li Zhu
doaj +1 more source
Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
doaj +1 more source
Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway. [PDF]
PLoS ONE, 2013 Class 3 semaphorins are well-known axonal guidance cues during the embryonic development of mammalian nervous system. However, their activity on postnatally differentiated neurons in neurogenic regions of adult brains has not been characterized. We found
Teclise Ng +6 more
doaj +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Receptor complexes for each of the Class 3 Semaphorins
Frontiers in Cellular Neuroscience, 2012 The Class 3 Semaphorins (Sema3s) are a sub-family of proteins whose known biological roles are varied and growing. The mechanism of action of the Sema3s requires binding to transmembrane receptors that comprise heteromeric complexes of Neuropilins ...
Alan R Harvey
doaj +1 more source
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source