Results 61 to 70 of about 2,294 (205)

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Semaphorins and neuropilins expression in salivary gland tumors

, 2015
BACKGROUND: Salivary gland tumors (SGT) account for 3-10% of all head and neck neoplasms, and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human ...
de Almeida, O.P., Mariano, F.V., Kowalski, L.P., de Andrade, B.A.B., Meurer, L., Martins, M.D., Speight, P.M., Rangel, A.L.C.A., Fonseca, F. P., Fonseca, F.P., Santos-Silva, A.R., de Andrade, B. A. B., Lopes, M.A., Santos-Silva, A. R., Lopes, M. A., de Almeida, O. P., Speight, P. M., Martins, M. D., Rangel, A. L. C. A., Mariano, F. V., Bingle, L., Vargas, P. A., Vargas, P.A., Kowalski, L. P.   +23 more
core   +1 more source

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels

Biomolecules, 2021
Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ quality of life.
Benjamin Neuditschko, Marlene Leibetseder, Julia Brunmair, Gerhard Hagn, Lukas Skos, Marlene C. Gerner, Samuel M. Meier-Menches, Iveta Yotova, Christopher Gerner   +8 more
doaj   +1 more source

Neuropilin Is a Semaphorin III Receptor [PDF]

Cell, 1997
The semaphorin family contains a large number of phylogenetically conserved proteins and includes several members that have been shown to function in repulsive axon guidance. Semaphorin III (Sema III) is a secreted protein that in vitro causes neuronal growth cone collapse and chemorepulsion of neurites, and in vivo is required for correct sensory ...
Kolodkin, Alex L, Levengood, Dorothy V, Rowe, Erica G, Tai, Yu-Tzu, Giger, Roman J, Ginty, David D   +5 more
openaire   +2 more sources

plexin-A4/plexin-D1 complexes convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins

, 2018
Class-3 semaphorin guidance factors bind to receptor complexes containing neuropilin and plexin receptors. A semaphorin may bind to several receptor complexes containing somewhat different constituents, resulting in diverse effects on cell migration ...
Ofra Kessler, Gera Neufeld, Tatyana Smolkin, Inbal Nir-Zvi, Yelena Mumblat, Nerri Duvshani   +5 more
core   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. [PDF]

PLoS ONE, 2014
The cancer associated class 3 semaphorins require direct binding to neuropilins and association to plexins to trigger cell signaling. Here, we address the role of the transmembrane domains of neuropilin 1 and plexin A1 for the dimerization of the two ...
Samia Aci-Sèche, Paul Sawma, Pierre Hubert, James N Sturgis, Dominique Bagnard, Laurent Jacob, Monique Genest, Norbert Garnier   +7 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Role of Neuropilins in regulating macrophage function and the development of atherosclerotic plaques in the mouse [PDF]

, 2022
Background. Ischaemic heart disease is the leading cause of mortality worldwide and atherosclerosis is the underlying pathology in most cases. Macrophages are heterogenous inflammatory cells that play a central role in the development of atherosclerosis.
Fernando-Sayers, Jacob
core  

Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer

Cancer Medicine, 2018
Neuropilins (NRPs) have been described as receptors for class 3 semaphorins and coreceptors for a plethora of ligands, such as members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines and transforming growth factor (TGF ...
Pratiek N. Matkar, Eric D. Jong, Ramya Ariyagunarajah, Gerald J. Prud'homme, Krishna K. Singh, Howard Leong‐Poi   +5 more
doaj   +1 more source