Results 141 to 150 of about 1,960 (180)

Neuropilins in physiological and pathological angiogenesis

Journal of Pathology, 2007
AbstractNeuropilin‐1 (Np1) and neuropilin‐2 (Np2) are transmembrane glycoproteins with large extracellular domains that interact with both class 3 semaphorins and vascular endothelial growth factor (VEGF), and are involved in the regulation of many physiological pathways, including angiogenesis. The neuropilins also interact directly with the classical
Malcolm W Reed, Nicola Brown, C A Staton   +2 more
exaly   +3 more sources

Role of neuropilins

2022
Domenico Ribatti
exaly   +2 more sources

Neuropilins in Tumor Biology

Clinical Cancer Research, 2009
Abstract The neuropilin receptors were first discovered as regulators of nervous system development, acting as semaphorin coreceptors with plexins. Subsequently, the neuropilins were identified as receptors for vascular endothelial growth factor.
Anil, Bagri, Marc, Tessier-Lavigne, Ryan J, Watts   +2 more
openaire   +2 more sources

Neuropilin is a Mediator of Angiogenesis

Cancer and Metastasis Reviews, 2000
Neuropilin is both a receptor for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is only beginning to be elucidated.
H Q, Miao, M, Klagsbrun
openaire   +2 more sources

Neuropilin regulation of angiogenesis

Biochemical Society Transactions, 2014
Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia, such as neovascular eye disease and cancer. Neuropilin 1 (NRP1) is a transmembrane protein that serves
Anastasia, Lampropoulou, Christiana, Ruhrberg   +1 more
openaire   +2 more sources

Multifaceted Role of Neuropilins in Cancer

Current Medicinal Chemistry, 2011
Neuropilins comprise two homologous widely-expressed single-pass plasma membrane receptors (Nrp1 and Nrp2), originally identified for binding secreted Semaphorins and Vascular Endothelial Growth Factors (in association with Plexins and VEGF-Receptors).
Rizzolio, S., Tamagnone, L.
openaire   +3 more sources

Neuropilin 2 and soluble neuropilin 2 in neuroendocrine neoplasms

Endocrine-Related Cancer
Neuropilin 2 (NRP2), a transmembrane non-tyrosine kinase receptor, has been described as a potential critical player in the tumourigenesis of several solid cancers and particularly in neuroendocrine neoplasms (NENs). A soluble form of NRP2 (sNRP2) has been previously described and corresponds to a truncated splice isoform.
Laura Gerard, Céline Patte, Laurence Chardon, Valérie Hervieu, Léa Payen, Marion Allio, Claire Marx, Hugo Clermidy, Alice Durand, Patrick Mehlen, Julien Bollard, Gilles Poncet, Colette Roche, Benjamin Gibert, Thomas Walter   +14 more
openaire   +2 more sources

The role of neuropilins in cancer

Molecular Cancer Therapeutics, 2006
Abstract Neuropilins are multifunctional non–tyrosine kinase receptors that bind to class 3 semaphorins and vascular endothelial growth factor. NRP-1 and NRP-2 were first identified for their key role in mediating axonal guidance in the developing nervous system through their interactions with class 3 semaphorins.
openaire   +2 more sources

Neuropilin signalling in angiogenesis

Biochemical Society Transactions, 2012
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases).
openaire   +2 more sources