Results 161 to 170 of about 2,294 (205)

Neuropilins

, 2008
exaly   +3 more sources

Neuropilins: A New Target for Cancer Therapy

Cancers, 2011
Recent investigations highlighted strong similarities between neural crest migration during embryogenesis and metastatic processes. Indeed, some families of axon guidance molecules were also reported to participate in cancer invasion: plexins/semaphorins/
Christophe Borg, Borg Christophe
exaly   +2 more sources

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Role of neuropilins

2022
Domenico Ribatti
exaly   +2 more sources

Novel svVEGF isoforms from Macrovipera lebetina venom interact with neuropilins

Biochemical and Biophysical Research Communications, 2009
International audienceIncreased vascular permeability and vasodilation are responses usually elicited by snake envenomation. In this report, we isolated from Macroviperalebetina venom two protein groups designated IC1 (Increasing Capillary1) and IC2 ...
Sylviane Hoos, Michael Klagsbrun, Patrick England   +2 more
exaly   +2 more sources

Characterization of Class-3 Semaphorin Receptors, Neuropilins and Plexins, as Therapeutic Targets in a Pan-Cancer Study

Cancers, 2020
Class-3 semaphorins (SEMA3s), initially characterized as axon guidance cues, have been recognized as key regulators for immune responses, angiogenesis, tumorigenesis and drug responses.
Xiaoli Zhang, , Lang Li
exaly   +2 more sources

Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury [PDF]

Cardiovascular Research, 2015
AIMS: Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth muscle cells (VSMCs) and are implicated in VSMC ...
Caroline Pellet-Many, Ian Evans, Ian Zachary   +2 more
exaly   +2 more sources

Neuropilins in Tumor Biology

Clinical Cancer Research, 2009
Abstract The neuropilin receptors were first discovered as regulators of nervous system development, acting as semaphorin coreceptors with plexins. Subsequently, the neuropilins were identified as receptors for vascular endothelial growth factor.
Anil, Bagri, Marc, Tessier-Lavigne, Ryan J, Watts   +2 more
openaire   +2 more sources

Neuropilin is a Mediator of Angiogenesis

Cancer and Metastasis Reviews, 2000
Neuropilin is both a receptor for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is only beginning to be elucidated.
H Q, Miao, M, Klagsbrun
openaire   +2 more sources

Neuropilin regulation of angiogenesis

Biochemical Society Transactions, 2014
Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia, such as neovascular eye disease and cancer. Neuropilin 1 (NRP1) is a transmembrane protein that serves
Anastasia, Lampropoulou, Christiana, Ruhrberg   +1 more
openaire   +2 more sources

Role of semaphorins, neuropilins and plexins in cancer progression

Cancer Letters
Progress in understanding nervous system-cancer interconnections has emphasized the functional role of semaphorins (SEMAs) and their receptors, neuropilins (NRPs) and plexins (PLXNs), in cancer progression.
Paloma Bragado
exaly   +2 more sources