Results 171 to 180 of about 2,294 (205)

Neuropilins in physiological and pathological angiogenesis

Journal of Pathology, 2007
AbstractNeuropilin‐1 (Np1) and neuropilin‐2 (Np2) are transmembrane glycoproteins with large extracellular domains that interact with both class 3 semaphorins and vascular endothelial growth factor (VEGF), and are involved in the regulation of many physiological pathways, including angiogenesis. The neuropilins also interact directly with the classical
Malcolm W R Reed, Nicola J Brown
exaly   +3 more sources

Neuropilin 2 and soluble neuropilin 2 in neuroendocrine neoplasms

Endocrine-Related Cancer
Neuropilin 2 (NRP2), a transmembrane non-tyrosine kinase receptor, has been described as a potential critical player in the tumourigenesis of several solid cancers and particularly in neuroendocrine neoplasms (NENs). A soluble form of NRP2 (sNRP2) has been previously described and corresponds to a truncated splice isoform.
Laura Gerard, Céline Patte, Laurence Chardon, Valérie Hervieu, Léa Payen, Marion Allio, Claire Marx, Hugo Clermidy, Alice Durand, Patrick Mehlen, Julien Bollard, Gilles Poncet, Colette Roche, Benjamin Gibert, Thomas Walter   +14 more
openaire   +2 more sources

The role of neuropilins in cancer

Molecular Cancer Therapeutics, 2006
Abstract Neuropilins are multifunctional non–tyrosine kinase receptors that bind to class 3 semaphorins and vascular endothelial growth factor. NRP-1 and NRP-2 were first identified for their key role in mediating axonal guidance in the developing nervous system through their interactions with class 3 semaphorins.
openaire   +2 more sources

Endothelial neuropilin-1 and neuropilin-2 are essential for tumour angiogenesis

2022
Abstract Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known co-receptors for vascular endothelial growth factor receptors (VEGFRs), core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting ...
CJ Benwell, RT Johnson, JAGE Taylor, CA Price, SD Robinson   +4 more
openaire   +1 more source

Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity

Blood, 2008
Neuropilin-1 and -2 (NRP1 and NRP2) are the transmembrane glycoproteins interacting with 2 types of ligands: class III semaphorins and several members of the VEGF family, the main regulators of blood and lymphatic vessel growth. We show here that both NRP1 and NRP2 can also bind hepatocyte growth factor (HGF).
Sulpice, Eric, Plouët, Jean, Bergé, Mathieu, Allanic, David, Tobelem, Gérard, Merkulova-Rainon, Tatyana   +5 more
openaire   +3 more sources

Neuropilin signalling in angiogenesis

Biochemical Society Transactions, 2012
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases).
openaire   +2 more sources

The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF

2002
The Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF).
Gera, Neufeld, Ofra, Kessler, Yael, Herzog   +2 more
openaire   +2 more sources

The role of neuropilins in cell signalling

Biochemical Society Transactions, 2009
NRPs (neuropilins) are receptors for class 3 semaphorins, polypeptides essential for axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines. While mutant mouse studies show that NRP1 is essential for neuronal and cardiovascular development, little is known concerning the molecular mechanisms ...
Ian C, Zachary, Paul, Frankel, Ian M, Evans, Caroline, Pellet-Many   +3 more
openaire   +2 more sources

Structural and Functional Relation of Neuropilins

2002
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and -2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a ...
Fumio, Nakamura, Yoshio, Goshima
openaire   +2 more sources

Neuropilin‐2 expression in cancer

Histopathology, 2012
Jubb A M, Sa S M, Ratti N, Strickland L A, Schmidt M, Callahan C A & Koeppen H 
(2012) Histopathology 61, 340–349Neuropilin‐2 expression in cancerAims:  Neuropilin‐2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin‐2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study
Adrian M, Jubb, Susan M, Sa, Navneet, Ratti, Laura A, Strickland, Maike, Schmidt, Christopher A, Callahan, Hartmut, Koeppen   +6 more
openaire   +2 more sources