Scientific Reports, 2017 Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its roles in brain injury models have not been fully understood.
Li D Zhang +8 more
semanticscholar +1 more source
Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]
, 2001 Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Behl, Christian +3 more
core +1 more source
Bioactivity of Olive Oil Phenols in Neuroprotection
International Journal of Molecular Sciences, 2017 Neurological disorders such as stroke, Alzheimer’s and Parkinson’s diseases are associated with high morbidity and mortality, and few or no effective options are available for their treatment.
C. Angeloni +3 more
semanticscholar +1 more source
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection
Frontiers in Endocrinology, 2018 Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide (NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in the human sirtuin family, among which SIRT1 is the most conserved and ...
Jing Xu +4 more
semanticscholar +1 more source
Glutathione-Mediated Neuroprotection Against Methylmercury Neurotoxicity in Cortical Culture is Dependent on MRP1 [PDF]
, 2012 Methylmercury (MeHg) exposure at high concentrations poses significant neurotoxic threat to humans worldwide. The present study investigated the mechanisms of glutathione-mediated attenuation of MeHg neurotoxicity in primary cortical culture. MeHg (5 μM)
Liu, Xiaoqian +4 more
core +1 more source
Neuroprotective Properties of Xenon. [PDF]
, 2020 Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils [PDF]
Brain Research 927(2): 212-215 (2002), 2007 Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils.
arxiv
Cyclooxygenase inhibition in ischemic brain injury [PDF]
Current Pharmaceutical Design 2008; 14(14):1401-1418, 2008 Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is known to be actively involved in the neuroinflammatory events leading to neuronal death after ischemia.
arxiv
Refocusing Neuroprotection in Cerebral Reperfusion Era: New Challenges and Strategies
Frontiers in Neurology, 2018 Pathophysiological processes of stroke have revealed that the damaged brain should be considered as an integral structure to be protected. However, promising neuroprotective drugs have failed when translated to clinical trials.
Xiao-Yi Xiong, Liang Liu, Qing-Wu Yang
semanticscholar +1 more source
Neuroprotection by excitatory amino acid antagonist augments the benefit of thrombolysis in embolic stroke in rats. [PDF]
, 1993 Tomas Sereghy +2 more
openalex +1 more source