Results 251 to 260 of about 174,148 (299)
Some of the next articles are maybe not open access.
Seminars in Neurology, 1998
Neuroprotective therapy for stroke remains unproven despite its ability to substantially reduce injury in animal stroke models. Based on an understanding of the cascade of biochemical events that follow interruption of blood flow to the brain, various neuroprotective drugs have been tested in clinical studies, but none have been shown to improve ...
S L, Hickenbottom, J, Grotta
openaire +3 more sources
Neuroprotective therapy for stroke remains unproven despite its ability to substantially reduce injury in animal stroke models. Based on an understanding of the cascade of biochemical events that follow interruption of blood flow to the brain, various neuroprotective drugs have been tested in clinical studies, but none have been shown to improve ...
S L, Hickenbottom, J, Grotta
openaire +3 more sources
Medical Clinics of North America, 1999
Though effective symptomatic therapies for Parkinson's disease exist, currently no treatment is proven to slow the progression of the underlying disease. Our growing understanding of the mechanisms of neuronal models, however, offers hope that neuroprotective strategies will soon be a standard part of the treatment of PD.
D K, Simon, D G, Standaert
openaire +2 more sources
Though effective symptomatic therapies for Parkinson's disease exist, currently no treatment is proven to slow the progression of the underlying disease. Our growing understanding of the mechanisms of neuronal models, however, offers hope that neuroprotective strategies will soon be a standard part of the treatment of PD.
D K, Simon, D G, Standaert
openaire +2 more sources
Cellular and Molecular Neurobiology, 2003
1. Stimulation of the rostral-ventromedial pole of the cerebellar fastigial nucleus exerts powerful effects on systemic and cerebral circulation. 2. Excitation of fibers passing through the fastigial nucleus evokes sympathoactivation and increases in arterial pressure. 3.
Eugene V, Golanov, Ping, Zhou
openaire +2 more sources
1. Stimulation of the rostral-ventromedial pole of the cerebellar fastigial nucleus exerts powerful effects on systemic and cerebral circulation. 2. Excitation of fibers passing through the fastigial nucleus evokes sympathoactivation and increases in arterial pressure. 3.
Eugene V, Golanov, Ping, Zhou
openaire +2 more sources
Best Practice & Research Clinical Anaesthesiology, 2010
The endpoint of all cerebral injuries like stroke, global cerebral ischemia during cardiac arrest, cardiac, vascular, or brain surgery or head trauma is the inadequate supply of the brain with oxygen and glucose, which triggers a characteristic pathophysiologic cascade leading to neuronal death. Many methods and agents have been investigated to produce
Klaus Ulrich, Klein, Kristin, Engelhard
openaire +2 more sources
The endpoint of all cerebral injuries like stroke, global cerebral ischemia during cardiac arrest, cardiac, vascular, or brain surgery or head trauma is the inadequate supply of the brain with oxygen and glucose, which triggers a characteristic pathophysiologic cascade leading to neuronal death. Many methods and agents have been investigated to produce
Klaus Ulrich, Klein, Kristin, Engelhard
openaire +2 more sources
Current Drug Targets, 2007
Ischemic brain injury can be anticipated in a number of clinical settings such as procedures associated with a high-risk for stroke, patients with transient ischemic attacks or minor strokes who are at substantial risk for early recurrence and patients with multiple vascular risk factors with an enhanced risk for ischemic stroke over many years.
Savitz, Sean I., Fisher, Marc
openaire +3 more sources
Ischemic brain injury can be anticipated in a number of clinical settings such as procedures associated with a high-risk for stroke, patients with transient ischemic attacks or minor strokes who are at substantial risk for early recurrence and patients with multiple vascular risk factors with an enhanced risk for ischemic stroke over many years.
Savitz, Sean I., Fisher, Marc
openaire +3 more sources
Cerebrovascular Diseases, 2000
The current goal of acute stroke therapy is to restore cerebral perfusion and to protect cerebral tissue before the development of an irreversible damage. This latter is due to the duration and the severity of cerebral ischemia [1]. Recanalization operated by thrombolysis represents the most intuitive and effective treatment of acute cerebral ischemia.
MOSTARDINI C +5 more
openaire +3 more sources
The current goal of acute stroke therapy is to restore cerebral perfusion and to protect cerebral tissue before the development of an irreversible damage. This latter is due to the duration and the severity of cerebral ischemia [1]. Recanalization operated by thrombolysis represents the most intuitive and effective treatment of acute cerebral ischemia.
MOSTARDINI C +5 more
openaire +3 more sources
2017
Abstract Acute cerebral injury sets into motion a cascade of deleterious biochemical events that cause further neuronal damage and amplify deleterious effects. This cascade develops over time and potentially may be attenuated or limited by pharmacologic manipulation.
Stocchetti, Nino, Carbonara, Marco
openaire +2 more sources
Abstract Acute cerebral injury sets into motion a cascade of deleterious biochemical events that cause further neuronal damage and amplify deleterious effects. This cascade develops over time and potentially may be attenuated or limited by pharmacologic manipulation.
Stocchetti, Nino, Carbonara, Marco
openaire +2 more sources
Physical Medicine and Rehabilitation Clinics of North America, 1999
Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
openaire +2 more sources
Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
openaire +2 more sources