Results 251 to 260 of about 177,883 (410)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Nanotechnology for ischemic stroke treatment: addressing challenges across stroke management stages. [PDF]

Front Mol Biosci
Wu Y, Wang L, Zou C, Meng X, Yang P, Zhang H.   +5 more
europepmc   +1 more source

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

Corrigendum to "Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons" [Mol. Cell. Endocrinol. 384 1-2 (2014) 52-60]. [PDF]

Mol Cell Endocrinol
Jayaraman A, Pike CJ.
europepmc   +1 more source

Timing-Dependent Cleavage of Interleukin-1 Receptor Antagonist by Alteplase Impairs Neuroprotection in Ischemic Stroke

Ioana‐Emilia Mosneag, Marina Rubio, Eloïse Lemarchand, Yolanda Ohene, Ben Dickie, Rachel Jones, Graham Coutts, Eleanor Ritchie, Daniela Martins Borges, Denis Vivien, Craig J. Smith, Stuart M. Allan   +11 more
openalex   +2 more sources

Mechanism of microglia neuroprotection: Involvement ofP2X7,TNFα, and valproic acid [PDF]

, 2015
Annette Masuch, Chu‐Hsin Shieh, Nico van Rooijen, Dietrich van Calker, Knut Biber   +4 more
openalex   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Antenatal magnesium sulphate for preterm foetal neuroprotection in low- and middle-income countries: a scoping review of research studies and guidelines. [PDF]

J Glob Health
Goldsmith S, Karim T, McIntyre S, Rumbold A, Malhotra A, Khandaker G, Arya S, Shepherd E.   +7 more
europepmc   +1 more source

Hypoxic-preconditioning induces neuroprotection against hypoxia–ischemia in newborn piglet brain

, 2011
Jahan Ara, Saskia Maria Wiegerinck Fekete, Melissa Frank, Jeffrey A. Golden, David Pleasure, Ignacio Valencia   +5 more
openalex   +2 more sources

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source