Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning [PDF]
Conditioning Medicine, 2018, 2019 Acute neuroprotection in numerous human clinical trials has been an abject failure. Major systemic-and procedural-based issues have subsequently been identified in both clinical trials and preclinical animal model experimentation. As well, issues related to the neuroprotective moiety itself have contributed to clinical trial failures, including late ...
arxiv
Perinatal neuroprotection [PDF]
F1000Prime Reports, 2014 Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E. +2 more
openaire +2 more sources
Preliminary Report: Cerebral blood flow mediates the relationship between progesterone and perceived stress symptoms among female club athletes after mild traumatic brain injury [PDF]
arXiv, 2020 Female athletes are severely understudied in the field of concussion research, despite higher prevalence for injuries and tendency to have longer recovery time. Hormonal fluctuations due to normal menstrual cycle (MC) or hormonal contraceptive (HC) use have been shown to impact both post-injury symptoms and neuroimaging measures, but have not been ...
arxiv
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]
Brain Research 1007(1-2): 98-108 (2004), 2007 Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebral ischemia in rats.
arxiv
Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress [PDF]
, 2014 Accepted: 8 January 2014 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acknowledgments
Alfonso, Amparo +9 more
core +4 more sources
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]
European Journal of Pharmacology 453(2-3): 189-195 (2002), 2007 Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global ...
arxiv
GRP78 at the Centre of the Stage in Cancer and Neuroprotection
Frontiers in Neuroscience, 2017 The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the ...
Caty Casas
semanticscholar +1 more source
The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy
Frontiers in Molecular Neuroscience, 2017 Astrocytes are commonly involved in negative responses through their hyperreactivity and glial scar formation in excitotoxic and/or mechanical injuries.
Andrea Becerra-Calixto +1 more
semanticscholar +1 more source
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
core +2 more sources
Aromatase: a neuroprotective enzyme [PDF]
Progress in Neurobiology, 2003 Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme catalyzes the conversion of testosterone and other C19 steroids to estradiol. Genetic or pharmacological inhibition
Roberto Cosimo Melcangi +5 more
openaire +5 more sources