Results 71 to 80 of about 149 (147)
iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Journal of Pediatric Neurosciences, 2011 Somsri Wiwanitkit, Viroj Wiwanitkit
openaire +3 more sources
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
iRADIOLOGY, EarlyView.This study demonstrates that the ratio of tNAA to tCr increases during gestation, which correlates with an increase in the number of neurons and cellular energy metabolism in the fetal brain as gestational weeks progress. Additionally, tCho levels exhibit a progressive decrease with advancing gestational weeks, indicating the ongoing development of the
Dejuan Shan +5 more
wiley +1 more source
Journal of Medical Radiation Sciences, EarlyView.A pre‐cannulation survey of the circle of Willis (CoW) using transcranial Doppler (TCD) ultrasound was implemented to assess cerebral collateral circulation in children undergoing VA ECMO or cardiac surgery with cervical cannulation. The technique, in use since 2019, employs high‐end ultrasound platforms to assess brain morphology, haemorrhage and ...
Tristan Reddan +3 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model.
Qun Cheng +2 more
wiley +1 more source
Relaxin‐2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study aims to assess the therapeutic effectiveness of Relaxin‐2 (RLN‐2) in promoting functional recovery and neuroprotection following spinal cord injury (SCI) in mice. Furthermore, continuous subcutaneous infusion of Serelaxin (0.5 mg/kg/day; human recombinant relaxin‐2) improved neurological recovery, as evidenced by higher Basso ...
Ji‐Huan Wang +2 more
wiley +1 more source
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Med Research, EarlyView.ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li +13 more
wiley +1 more source
Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform
Movement Disorders, EarlyView.Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles +29 more
wiley +1 more source