Results 71 to 80 of about 208,629 (380)
Targeting brain‐derived neurotrophic factor in the treatment of neurodegenerative diseases: A review
NeuroprotectionNeurodegenerative diseases, marked by the gradual death of neurons, present a significant and growing public health challenge. Brain‐derived neurotrophic factor (BDNF) is crucial for the survival, development, and synaptic plasticity of neurons.
Dong Wang +4 more
doaj +1 more source
Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction
Cell Death and Disease, 2018 Trehalose is a non-reducing disaccharide with two glucose molecules linked through an α, α-1,1-glucosidic bond. Trehalose has received attention for the past few decades for its role in neuroprotection especially in animal models of various ...
He‐Jin Lee, Y. Yoon, Seung-Jae Lee
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim +12 more
wiley +1 more source
Data in Brief, 2020 This article provides information regarding the effect of four common high abundant protein (albumin and immunoglobulins (Ig)) depletion strategies upon serum proteomics datasets derived from normal, non-diseased rat or human serum. After tryptic digest,
Bharani Thangavelu +4 more
doaj
Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection
Journal of Cerebral Blood Flow and Metabolism, 2018 Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the anesthesiologist.
Andrew M. Slupe, J. Kirsch
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
EMBO Molecular Medicine, 2019 Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions.
Fabien Binamé +12 more
doaj +1 more source
Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]
, 2012 Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
core +2 more sources
Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
Oxidative Medicine and Cellular Longevity, 2016 Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in the developing, adult, and aging nervous system.
L. Costa +3 more
semanticscholar +1 more source
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
Advanced Healthcare Materials, EarlyView.A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum +28 more
wiley +1 more source