Results 81 to 90 of about 174,618 (333)

Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells after Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

Cell Transplantation, 2016
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains.
Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai   +12 more
doaj   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Choroid Plexus Fibroblast–ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury

Advanced Science, EarlyView.
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong   +10 more
wiley   +1 more source

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
core   +1 more source

Salsolinol—neurotoxic or Neuroprotective? [PDF]

Neurotoxicity Research, 2019
AbstractSalsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged.
Magdalena Kurnik-Łucka, Gniewomir Latacz, Adrian Martyniak, Andrzej Bugajski, Katarzyna Kieć-Kononowicz, Krzysztof Gil   +5 more
openaire   +4 more sources

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Sex differences in the role of AKAP12 in behavioral function of middle-aged mice

Biology of Sex Differences
A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules.
Hidehiro Ishikawa, Shintaro Kimura, Hajime Takase, Maximillian Borlongan, Norito Fukuda, Tomonori Hoshino, Gen Hamanaka, Ji Hyun Park, Akihiro Shindo, Kyu-Won Kim, Irwin H. Gelman, Josephine Lok, Eng H. Lo, Ken Arai   +13 more
doaj   +1 more source

Comprehensive Insights into Tracheoesophageal Fistula Pathophysiology, Diagnosis, Treatment, and Future Directions

Advanced Science, EarlyView.
Tracheoesophageal fistula (TEF), a pathological trachea‐esophagus connection, arises congenitally or from malignancy/radiotherapy/trauma, causing aspiration and malnutrition. Diagnosis utilizes imaging and endoscopy. Treatment ranges from endoscopic stenting to surgical repair and conservative management.
Gang Li, Zhe Wang, Jia Liu, Shenbo Fu, Longmei Xue, Zijun Liao, Rong Yang, Shanping Huang, Rui Xu, Peng Chen, Yong Chen   +10 more
wiley   +1 more source

The Relevance and Implications of Monoclonal Antibody Therapies on Traumatic Brain Injury Pathologies

Biomedicines
Traumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction ...
Ping Wang, Starlyn Okada-Rising, Anke H. Scultetus, Zachary S. Bailey   +3 more
doaj   +1 more source