Results 81 to 90 of about 183,131 (255)
Vagus nerve manipulation and microglial plasticity in the prenatal brain [PDF]
arXiv, 2022 The efferent and afferent effects of the vagus nerve on the developing brain have remained enigmatic. Here we review the evidence of such effects on microglial plasticity in the sheep model of human fetal development, one of the most recognized and deployed models of human fetal physiology.
arxiv
Frontiers in Neuroscience, 2018 Sex steroid hormones are synthesized from cholesterol and exert pleiotropic effects notably in the central nervous system. Pioneering studies from Baulieu and colleagues have suggested that steroids are also locally-synthesized in the brain.
N. Diotel +8 more
semanticscholar +1 more source
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Ageing Research Reviews, 2021 J. Burtscher +3 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2019 Oxidative stress and neuroinflammation are considered the major central events in the process of Parkinson’s disease (PD). Nrf2 is a key regulator of endogenous defense systems. New finds have contacted activation of Nrf2 signaling with anti-inflammatory
Bei Zhang +6 more
semanticscholar +1 more source
Modulation of neurotrophic signaling pathways by polyphenols [PDF]
, 2015 Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza +3 more
core +1 more source
Frontiers in Immunology, 2019 Background: Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease and characterized by slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra.
Ce Chen +6 more
semanticscholar +1 more source
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
Neuroscience Research 47(2): 245-253 (2003), 2007 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury.
arxiv
Inflammatory neuroprotection following traumatic brain injury
Science, 2016 Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system (CNS) that involves both resident and peripheral immune cells.
Matthew V. Russo, D. McGavern
semanticscholar +1 more source
The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]
, 2017 α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles +4 more
core +1 more source
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats [PDF]
Brain Research 990(1-2): 1-7 (2003), 2007 Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of this study was to assess the neuroprotective effect and the neurological outcome after pyruvate administration in a model of ischemic stroke induced by permanent middle ...
arxiv