Results 1 to 10 of about 339,661 (301)
Cell Reports, 2023 Summary: Neutrophil aggregation and clearance are important factors affecting neuroinflammatory injury during acute ischemic stroke. Emerging evidence suggests that energy metabolism is essential for microglial functions, especially microglial ...
Lei Li +9 more
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Frontiers in Cell and Developmental Biology, 2021 Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in
Jifeng Zhao +7 more
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Cell Death and Disease, 2021 Extracellular vesicles (EVs), as a novel intercellular communication carrier transferring cargo microRNAs (miRNAs), could play important roles in the brain remodeling process after ischemic stroke. However, the detailed mechanisms involved in EVs derived
Jin Yang +10 more
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Frontiers in Cell and Developmental Biology, 2020 A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opioids. Endoplasmic reticulum (ER) stress has been shown to contribute to neuropathic or inflammatory pain, but its ...
Tong-Tong Lin +10 more
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Acta Pharmaceutica Sinica B, 2022 The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog of S1P) promoted microglial phagocytosis in stroke independent of S1PRs.
Tengfei Xue +9 more
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Potential antidepressant effects of scutellaria baicalensis, hericium erinaceus and rhodiola rosea [PDF]
, 2020 Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of
Biagioni, F +5 more
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Frontiers in Molecular Neuroscience, 2017 There is increasing interest in the association between depression and the development of metabolic diseases. Rosiglitazone, a therapeutic drug used to treat type 2 diabetes mellitus, has shown neuroprotective effects in patients with stroke and ...
Zhan Zhao +10 more
doaj +1 more source
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats
Journal of Pharmacological Sciences, 2017 Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods. In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163.
Teng-Fei Xue +7 more
doaj +1 more source
Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease [PDF]
, 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
Counsell, Carl +4 more
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A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways). [PDF]
, 2014 Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological ...
Applegate, Patricia M +5 more
core +6 more sources