Results 1 to 10 of about 114,437 (95)

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement ...
A Compston, AJ Coles, BB Thomas, C Bjartmar, CKS Leung, D Baker, DA Bechtold, David Baker, DB Fernandes, DW Hampton, E Bettelli, E Bettelli, F Hafezi, G Feng, G Pryce, Gavin Giovannoni, J Goverman, J Oh, JA Black, JA Cohen, JK O’Neill, JM Coquet, K Raju, Katie Lidster, KM Galetta, L Steinman, LS Talman, LS Talman, M Kleinewietfeld, Mark D. Baker, MM Morris-Downes, Pablo Villoslada, Pete Coffey, Peter Munro, R Dutta, R Kapoor, S Al-Izki, S Al-Izki, S Al-Izki, S Gnanapavan, S Mader, Samuel J. Jackson, SG Waxman, SJ Piddlesden, T Hayton, T Svingen, X Wang, Y Guan, Z Ahmed, Zubair Ahmed   +49 more
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Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source

Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data. [PDF]

, 2012
Aim: This study aimed to systematically review the preclinical data of neuroprotective agents for Parkinson's disease (PD) to support the translation of these compounds. Methods: The study consisted of two phases.
Bavelaar, B.M., Douna, H., Olivier, B., Pellikaan, H., Pieters, T.   +4 more
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [PDF]

, 2019
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency.
Evans, David, Fernández-Bolaños Guzmán, José María, López López, Óscar, Man,Teresa, Martins, Alice, Matos, Ana M. de, Oliveira, Maria Conceição, Rauter, Amélia P., Walter, Magnus   +8 more
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Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]

, 2016
Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross, Bajgar, Baker, Barkus, Battaglia, Bengtson, Beverly A. Huang, Campbell, Chemical Hazards Emergency Medical Management, de Araujo Furtado, DeLorenzo, DeLorenzo, Deshpande, Deshpande, Deshpande, Deshpande, Deshpande, Faure, Filbert, Grynkiewicz, Haley, Helmstaedter, Hood, Konradsen, Kristin F. Phillips, Laxmikant S. Deshpande, Li, Li, Loubinoux, Nagarkatti, Neligan, Niebauer, Peng, Phillips, Raghupathi, Raza, Robert E. Blair, Robert J. DeLorenzo, Rod, Savage, Sellstrom, Than, Truitt, Tuovinen   +43 more
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Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial [PDF]

, 2009
<p><b>Background and Purpose:</b>Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients.
Alger, J.R., Chen, C., Davis, S.M., De Silva, D.A., Kidwell, C.S., Lees, K.R., Muir, K.W., Saver, J.L., Starkman, S., Weir, C.J.   +9 more
core   +1 more source

Thioflavones as novel neuroprotective agents [PDF]

, 2016
Oxidative stress is associated with the pathology of neurodegenerative diseases. Identification of small molecules capable of protecting against oxidative stress is therefore of significant importance.
Corona, Giulia, Greco, Francesca, Hogan, Stephanie M., Osborn, Helen M. I., Ravishankar, Divyashree, Spencer, Jeremy P. E.   +5 more
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Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]

, 2017
Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat, Applegate, Richard, Araujo, Camila, Ho, Wing Mann, Huang, Lei, Reis, Cesar, Zhang, John H   +6 more
core   +3 more sources

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo, Fiebich, Bernd L., García-Cabrera, Michel, González-Falcón, Armando, León, Olga S.   +4 more
core   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
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