Results 11 to 20 of about 73,411 (161)

Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Chemical and natural toxic compounds can harm human health through a variety of mechanisms. Nowadays, herbal therapy is widely accepted as a safe method of treating toxicity.
Aidin Mohammadi Zonouz, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

Molecules, 2022
Neurodegenerative diseases (NDDs) are the main cause of dementia in the elderly, having no cure to date, as the currently available therapies focus on symptom remission.
Leila Elyasi, Jessica M. Rosenholm, Fatemeh Jesmi, Mehrdad Jahanshahi   +3 more
doaj   +1 more source

Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies

Brain Circulation, 2022
Ischemic stroke is a disease with worldwide economic and social negative effects. It is a serious disease with high disability and mortality. Ionic imbalance, excitotoxicity, oxidative stress, and inflammation are induced during and after ischemic stroke.
Fettah Eren, Sueda Ecem Yilmaz
doaj   +1 more source

In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats

Molecules, 2022
Multiple sclerosis is a chronic autoimmune disorder that leads to the demyelination of nerve fibers, which is the major cause of non-traumatic disability all around the world. Herbal plants Nepeta hindustana L., Vitex negundo L., and Argemone albiflora L.
Rabia Rasool, Inam Ullah, Samiah Shahid, Bismillah Mubeen, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Sami I. Alzarea, Bibi Nazia Murtaza, Muhammad Shahid Nadeem, Imran Kazmi   +10 more
doaj   +1 more source

Therapeutic potential of agmatine in the experimental autoimmune encephalomyelitis [PDF]

Vojnosanitetski Pregled, 2021
Background/Aim. Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS), in which we investigated the neuroprotective effect of agmatine (AGM), known as a primary amine produced via the decarboxylation of L-arginine. Methods.
Stevanović Ivana, Ninković Milica, Stanojević Jelena, Mančić Bojana, Stojanović Ivana   +4 more
doaj   +1 more source

Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease

Frontiers in Chemistry, 2022
A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s ...
Ladan Pourabdi, Tuba Tüylü Küçükkılınç, Fatemeh Khoshtale, Beyza Ayazgök, Hamid Nadri, Farid Farokhi Alashti, Hamid Forootanfar, Tayebeh Akbari, Mohammad Shafiei, Alireza Foroumadi, Alireza Foroumadi, Mohammad Sharifzadeh, Mehdi Shafiee Ardestani, M. Saeed Abaee, Loghman Firoozpour, Mehdi Khoobi, Mehdi Khoobi, Mohammad M. Mojtahedi   +17 more
doaj   +1 more source

Evaluation of the neuroprotective activity of a new allylmorpholine derivative in a rat model of traumatic brain injury

Разработка и регистрация лекарственных средств, 2021
Introduction. The search for and development of new drugs capable of reducing the severity of neurological deficit in traumatic brain injury are a critical task for investigational pharmacology.
V. A. Prikhodko, A. V. Kan, Yu. I. Sysoev, I. A. Titovich, N. A. Anisimova, S. v Okovityi   +5 more
doaj   +1 more source

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism

Molecules, 2020
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life.
Masaru Tanaka, Zsuzsanna Bohár, László Vécsei   +2 more
doaj   +1 more source

Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein [PDF]

BioImpacts, 2022
Introduction: Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of
Raja Rajeswari Rajeshkumar, Banoth Karan Kumar, Pavadai Parasuraman, Theivendren Panneerselvam, Krishnan Sundar, Damodar Nayak Ammunje, Sureshbabu Ram Kumar Pandian, Sankaranarayanan Murugesan, Shanmugampillai Jeyarajaguru Kabilan, Selvaraj Kunjiappan   +9 more
doaj   +1 more source

Neuroprotective Properties of Chitosan and Its Derivatives

Marine Drugs, 2010
Neuronal cells are extremely vulnerable and have a limited capacity for self-repair in response to injury. For those reasons, there is obvious interest in limiting neuronal damage.
Se-Kwon Kim, Ratih Pangestuti
doaj   +1 more source