Results 31 to 40 of about 73,411 (161)

Impact of neuroprotective agents on mortality and neurological outcomes in traumatic brain injury patients from road traffic accidents

Asian Journal of Medical Sciences
Background: Traumatic brain injuries (TBIs) are a leading cause of morbidity and mortality worldwide, particularly those resulting from road traffic accidents. Secondary brain injury mechanisms, such as inflammation and oxidative stress, play significant
Shivam Sharma , Dinesh Shukla , Sanjay Chaube , Naseem Akram   +3 more
doaj   +1 more source

Will Cannabigerol Trigger Neuroregeneration after a Spinal Cord Injury? An In Vitro Answer from NSC-34 Scratch-Injured Cells Transcriptome

Pharmaceuticals, 2022
Spinal cord injury affects the lives of millions of people around the world, often causing disability and, in unfortunate circumstances, death. Rehabilitation can partly improve outcomes and only a small percentage of patients, typically the least ...
Andrea Valeri, Luigi Chiricosta, Agnese Gugliandolo, Federica Pollastro, Emanuela Mazzon   +4 more
doaj   +1 more source

Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates

Molecules, 2017
Melatonin possesses potential efficacy in perinatal brain injuries, and has been proposed as adjunctive pharmacological therapy in combination with hypothermia in the clinical setting.
Silvia Carloni, Fabrizio Proietti, Marco Rocchi, Mariangela Longini, Lucia Marseglia, Gabriella D’Angelo, Walter Balduini, Eloisa Gitto, Giuseppe Buonocore   +8 more
doaj   +1 more source

Piracetam in Postconcussion Syndrome: preliminary results of a randomised study using SPECT [PDF]

The Indian Journal of Neurotrauma, 2007
Aim of this study was to study the changes in regional cerebral perfusion following administration of the drug piracetam using single photon emission computed tomography (SPECT) in patients with postconcussion syndrome (PCS).
Deepak Agrawal, NK Gowda
doaj  

The use of Thiocetam in the complex therapy of combat-related brain contusion

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Each patient presents a unique set of characteristics and challenges when it comes to acute cerebral ischemia resulting from craniocerebral injury.
I. F. Bielenichev, K. Yu. Nerianov, V. I. Chernii, D. A. Sereda, L. I. Kucherenko, N. V. Derevianko, К. І. Kandybei   +6 more
doaj   +1 more source

Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics

Cells
Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in schizophrenia and Parkinson’s disease but is limited by acute motor activity impairments (e.g., ataxia).
Diána Martos, Bálint Lőrinczi, István Szatmári, László Vécsei, Masaru Tanaka   +4 more
doaj   +1 more source

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range.
Rita Meleddu, Simona Distinto, Roberto Cirilli, Stefano Alcaro, Matilde Yanez, Maria Luisa Sanna, Angela Corona, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Elias Maccioni   +11 more
doaj   +1 more source

Effect of Oral Administration of S-allyl Cysteine (the Active Ingredient in the Aged Garlic Extract) on the Symptoms of Multiple Sclerosis in the Experimental Model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Autoimmune inflammation of the central nervous system followed by myelin destruction,  oxidative stress, and reduced neuroprotective factors play key roles in the pathogenesis of multiple sclerosis (MS). S-allyl cysteine (SAC),
Hossein Zeinali, Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +2 more
doaj  

Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

Molecules, 2015
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance.
Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre   +5 more
doaj   +1 more source

Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra

Marine Drugs, 2019
So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge
Maria Miguel-Gordo, Sandra Gegunde, Kevin Calabro, Laurence K. Jennings, Amparo Alfonso, Grégory Genta-Jouve, Jean Vacelet, Luis M. Botana, Olivier P. Thomas   +8 more
doaj   +1 more source