A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion. [PDF]
PLoS Computational Biology, 2013 Neurotransmitter release depends on the fusion of secretory vesicles with the plasma membrane and the release of their contents. The final fusion step displays higher-order Ca(2+) dependence, but also upstream steps depend on Ca(2+).
Alexander M Walter +3 more
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Neurosecretion Competence [PDF]
Journal of Biological Chemistry, 2002 The phenotype of neurosecretory cells is characterized by clear vesicles and dense granules, both discharged by regulated exocytosis. However, these organelles are lacking completely in a few neurosecretion-incompetent clones of the pheochromocytoma PC12
Christophe Grundschober +5 more
openaire +2 more sources
A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. [PDF]
PLoS Genetics, 2008 For most organisms, food is only intermittently available; therefore, molecular mechanisms that couple sensation of nutrient availability to growth and development are critical for survival. These mechanisms, however, remain poorly defined.
Brian H Lee, Kaveh Ashrafi
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REST-governed gene expression profiling in a neuronal cell model reveals novel direct and indirect processes of repression and up-regulation. [PDF]
Frontiers in Cellular Neuroscience, 2015 The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes,
Jose M. eGarcia-Manteiga +8 more
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Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies [PDF]
Cells, 2022 This study was conducted on 16 adult specimens of molly fish (Poecilia sphenops) to investigate ependymal cells (ECs) and their role in neurogenesis using ultrastructural examination and immunohistochemistry.
Doaa M. Mokhtar +4 more
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Editorial: The Phylogenetic History of Hypothalamic Neuromodulators [PDF]
Frontiers in Neuroscience, 2021 Jackson C. Bittencourt +3 more
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Editorial: Advances in research on the role of inflammation in gut functional disorders [PDF]
Frontiers in Physiology, 2023 Li-Fei Zheng, Sumei Liu, Jin-Xia Zhu
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Designing New Natural-Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research. [PDF]
Angew Chem Int Ed EnglWe report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Schlichter A +29 more
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Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation. [PDF]
Angew Chem Int Ed EnglAl3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Chen SH, Gu C, Huang XJ, Ewing AG.
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ACTION OF INSECT NEUROSECRETION UPON CENTRAL NERVOUS SYSTEM IN VITRO AND UPON BEHAVIOR
Proceedings of the National Academy of Sciences of the United States of America, 1958 S. Ozbas, E. S. Hodgson
exaly +2 more sources