Multiple functional neurosteroid binding sites on GABAA receptors. [PDF]
PLoS Biology, 2019 Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Zi-Wei Chen +12 more
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Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis [PDF]
Frontiers in Cellular Neuroscience, 2015 Corticosterone is known to accumulate in brain after various stressors including alcohol intoxication. Just as severe alcohol intoxication is typically required to impair memory formation only high concentrations of ethanol (60mM) acutely inhibit long ...
Yukitoshi eIzumi +2 more
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Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth [PDF]
Frontiers in Cellular NeurosciencePreterm birth substantially elevates the risk of neurological and cognitive disorders. Recent evidence suggests that the abrupt loss of placental support, particularly the cessation of neurotrophic and neuroprotective hormones, alters neurodevelopmental ...
Helene Lacaille +4 more
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The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]
, 2019 Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Corey Webster
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Medicines for Anxiety: A Hundred Years of Tranquillity and More to Come? [PDF]
Hum PsychopharmacolHuman Psychopharmacology: Clinical and Experimental, Volume 41, Issue 2, March 2026.
Nutt D.
europepmc +2 more sources
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC [PDF]
, 2018 Wayland W.L. Cheng +10 more
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Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior
Biomolecules, 2023 Among female rats, some individuals show estrus cycle-dependent irritability/aggressive behaviors, and these individual rats may be used as a model for premenstrual dysphoric disorder (PMDD). We wanted to investigate if these behaviors are related to the
Torbjörn Bäckström +7 more
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Biomolecules, 2023 Objectives In Vitro: To study the effects of GR3027 (golexanolone) on neurosteroid-induced GABA-mediated current responses under physiological GABAergic conditions with recombinant human α5β3γ2L and α1β2γ2L GABAA receptors expressed in human embryonic ...
Sara K. S. Bengtsson +7 more
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The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis. [PDF]
PLoS ONE, 2015 Neurosteroids can modulate the activity of the GABAA receptors, and thus affect anxiety-like behaviors. The non-benzodiazepine anxiolytic compound etifoxine has been shown to increase neurosteroid concentrations in brain tissue but the mode of action of ...
Jean Luc do Rego +2 more
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Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review
Frontiers in Psychiatry, 2023 With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis,
Rafał Marecki +4 more
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