Results 11 to 20 of about 12,549 (250)
Neurosteroids and Seizure Activity [PDF]
Frontiers in Endocrinology, 2020 Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available antiepileptic drugs so newer pharmacological treatment options have been continuously searched for. In this context, a group of endogenous or exogenous neurosteroids allosterically positively modulating GABA-A receptors may offer a promising approach. Among
Barbara Miziak +2 more
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Research topic: neurosteroids [PDF]
Frontiers in Endocrinology, 2012 Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration does not affect the concentration of pregnenolone, dehydroepiandrosterone, and their sulfate esters in the ...
Vaudry, Hubert, Tsutsui, Kazuyoshi
openaire +3 more sources
Neurobiology of Stress, 2020 Cognitive dysfunction, dementia and Alzheimer's disease (AD) are increasing as the population worldwide ages. Therapeutics for these conditions is an unmet need.
S.K.S. Bengtsson +6 more
doaj +1 more source
Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
core +2 more sources
Brain-Derived Estrogen and Neurological Disorders
Biology, 2022 Astrocytes and neurons in the male and female brains produce the neurosteroid brain-derived 17β-estradiol (BDE2) from androgen precursors. In this review, we discuss evidence that suggest BDE2 has a role in a number of neurological conditions, such as ...
Darrell W. Brann +7 more
doaj +1 more source
Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
eLife, 2020 This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not its
Yusuke Sugasawa +12 more
doaj +1 more source
Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice
Biology, 2023 17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models.
Jing Wang +6 more
doaj +1 more source
The Ability of Pregnenolone in Proliferation of Mouse Neural Stem Cells and Reduction of Inflammatory and Oxidant Markers after Induction of Inflammation with Lipopolysaccharide in Vitro [PDF]
Armaghane Danesh Bimonthly Journal, 2023 Background & aim: Pregnenolone acts as a precursor to other steroid hormones and exerts its effect as an anti-inflammatory molecule to maintain immune homeostasis in various inflammatory conditions. In these diseases, a decrease in the level ofP has been
K Negintaji +3 more
doaj
Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation [PDF]
, 2011 Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons.
Izumi, Yukitoshi +2 more
core +2 more sources
Molecules, 2023 Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical ...
Luis Ángel Flores-Aguilar +6 more
doaj +1 more source