Results 31 to 40 of about 12,549 (250)

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecules, 2021
In this study, we investigated the delivery of synthetic neurosteroids into MCF-7 human breast adenocarcinoma cells via Organic Anionic Transporting Polypeptides (OATPs) (pH 7.4 and 5.5) to identify the structural components required for OATP-mediated ...
Santosh Kumar Adla, Arun Kumar Tonduru, Thales Kronenberger, Eva Kudova, Antti Poso, Kristiina M. Huttunen   +5 more
doaj   +1 more source

Migraine and cluster headache show impaired neurosteroids patterns [PDF]

, 2019
Background: Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Capi, M., Cicione, C., De Marco, C. M., Di Menna, L., Guglielmetti, M., Koverech, A., Lionetto, L., Maestri, M., Martelletti, P., Negro, A., Nicoletti, F., Passariello, F., Sabbatini, E., Simmaco, M.   +13 more
core   +1 more source

Gestational or acute restraint in adulthood reduces levels of 5α-reduced testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male rats

Frontiers in Cellular Neuroscience, 2012
Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of ...
Alicia A Walf, Cheryl A Frye
doaj   +1 more source

Neurosteroids and Focal Epileptic Disorders [PDF]

International Journal of Molecular Sciences, 2020
Neurosteroids are a family of compounds that are synthesized in principal excitatory neurons and glial cells, and derive from the transformation of cholesterol into pregnenolone. The most studied neurosteroids—allopregnanolone and allotetrahydrodeoxycorticosterone (THDOC)—are known to modulate GABAA receptor-mediated transmission, thus playing a role ...
Lévesque Maxime, Biagini Giuseppe, Avoli Massimo   +2 more
openaire   +2 more sources

A TSPO ligand is protective in a mouse model of multiple sclerosis. [PDF]

, 2013
Local production of neurosteroids such as progesterone and allopregnanolone confers neuroprotection in central nervous system (CNS) inflammatory diseases.
Chechneva, Olga V, Daugherty, Daniel J, Deng, Wenbin, Liu, Xiao-Bo, Pleasure, David E, Selvaraj, Vimal   +5 more
core   +2 more sources

Neuroprotective Actions of Neurosteroids [PDF]

Frontiers in Endocrinology, 2011
Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation of ionotropic receptors.
Kinga eBorowicz, Stanislaw eCzuczwar, Stanislaw eCzuczwar, Barbara ePiskorska, Monika eBanach   +4 more
openaire   +3 more sources

New Biosynthesis and Biological Actions of Avian Neurosteroids

Journal of Experimental Neuroscience, 2013
De novo neurosteroidogenesis from cholesterol occurs in the brain of various avian species. However, the biosynthetic pathways leading to the formation of neurosteroids are still not completely elucidated.
Kazuyoshi Tsutsui, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Takayoshi Ubuka, Megumi Hatori, Tsuyoshi Hirota, Yoshitaka Fukada   +7 more
doaj   +1 more source

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

Frontiers in Pharmacology, 2018
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamate ...
Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Pavla Hubalkova, Barbora Krausova, Tereza Smejkalova, Michaela Nekardova, Michaela Nekardova, Marketa Smidkova, Lenka Monincova, Radko Soucek, Ladislav Vyklicky, Eva Kudova   +14 more
doaj   +1 more source

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Frontiers in Pharmacology, 2022
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy.
Makoto Ishikawa, Makoto Ishikawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Toru Nakazawa, Hiroshi Kunikata, Hiroshi Kunikata, Kota Sato, Kota Sato, Takeshi Yoshitomi, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Douglas F. Covey, Charles F. Zorumski, Charles F. Zorumski, Charles F. Zorumski, Yukitoshi Izumi, Yukitoshi Izumi, Yukitoshi Izumi   +22 more
doaj   +1 more source

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source