Results 41 to 50 of about 12,549 (250)

Glia–neuron interactions: Neurosteroids [PDF]

Epilepsia, 2010
SummaryGlial cells have both beneficial and detrimental effects on recovery from brain damage and play a role in epileptogenesis. Herein, we summarize evidence indicating that the ability of astrocytes to produce neurosteroids that reinforce γ‐aminobutyric acid receptor A (GABAA) functions impinge on epileptogenesis, as shown in temporal lobe epilepsy ...
BIAGINI, Giuseppe, M. Avoli
openaire   +1 more source

Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons

Frontiers in Cellular Neuroscience, 2019
We investigated effects of the neuroactive steroid anesthetic alfaxalone on intrinsic excitability, and on inhibitory and excitatory synaptic transmission to hypoglossal motor neurons (HMNs).
Cora Lau, Prajwal P. Thakre, Mark C. Bellingham   +2 more
doaj   +1 more source

A clickable oxysterol photolabel retains NMDA receptor activity and accumulates in neurons [PDF]

, 2018
Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Benz, Ann, Chen, Daniel M, Covey, Douglas F, Mennerick, Steven, Qian, Mingxing, Ziolkowski, Luke, Zorumski, Charles F   +6 more
core   +3 more sources

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration [PDF]

, 2012
Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in ...
A Agrawal, A Pierucci-Lagha, A Ruiz, AR Yang, C Fahlke, C Schwarzer, CI Dixon, CI Dixon, Claire I. Dixon, D Belelli, David N. Stephens, DM Dick, E Persohn, GJ Lydall, HH Samson, HJ Edenberg, HL June, HM Haughey, HV Morris, HV Morris, I Ponomarev, J Covault, J Lappalainen, JE Kralic, JE Kralic, JL Weiner, JT Sakai, K Low, KA Wafford, M Roberto, M Tauber, M Wakita, MA Enoch, MA Enoch, ML Barbaccia, N Onori, PA Lind, PJ Zhu, RT Khisti, Rudolph Uwe, S Bohlhalter, S Hansen, S Pirker, S Ueno, Sarah L. King, Sophie E. Walker, YA Blednov   +46 more
core   +7 more sources

Lack of neurosteroid selectivity at δ vs. γ2-containing GABAA receptors in dentate granule neurons [PDF]

, 2020
GAB
Lu, Xinguo, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +1 more source

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]

, 2016
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol, Coronel, Maria Florencia, de Nicola, Alejandro Federico, Gonzalez, Susana Laura, Labombarda, Maria Florencia, Raggio, María Celeste, Sánchez Granel, María Luz   +6 more
core   +2 more sources

Defining the end point of status epilepticus: A scoping review and framework for standardization

Epilepsia, EarlyView.
Abstract Status epilepticus (SE) is a life‐threatening neurological emergency with consensus‐driven definitions for onset but no standardized criteria for its end point. This gap creates uncertainty in research and clinical practice. We conducted a scoping review to evaluate how end points have been defined in SE research and to identify key areas of ...
Fawad A. Khan, Margaret T. Gopaul, Samuel L. Carter, Anil Chimakurthy, Summer Skelton, Lawrence J. Hirsch, Eugen Trinka   +6 more
wiley   +1 more source

Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients

Biomolecules
Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions and regulate neuroinflammation.
Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli   +7 more
doaj   +1 more source

Investigating the Synergistic Effect of Palmitoylethanolamide and Ganaxolone in PTZ-induced Tonic-clonic Seizures

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Anticonvulsive effects of neurosteroids were shown in animal models. Endocannabinoids modulate neuronal excitability. In this study, we investigated the synergism of the simultaneous application of Palmitoylethanolamide (PEA) as an ...
Hesamodin Bagheripoor, Abbas Alimoradian, Mehdi Sadegh   +2 more
doaj  

Measurement of steroid concentrations in brain tissue: methodological considerations

Frontiers in Endocrinology, 2011
It is well recognized that steroids are synthesized de novo in the brain (neurosteroids). In addition, steroids circulating in the blood enter the brain.
Matthew D Taves, Matthew D Taves, Chunqi eMa, Sarah A Heimovics, Colin J Saldanha, Colin J Saldanha, Kiran K Soma, Kiran K Soma, Kiran K Soma   +8 more
doaj   +1 more source