Results 171 to 180 of about 12,871 (217)
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Dehydroepiandrosterone – a neurosteroid
European Journal of Clinical Investigation, 2000Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells.
Friess, E. +3 more
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Pharmacological Research, 2020
Extensive progress has been made to understand the pathophysiology of stroke but it is still a major cause of mortality and disability worldwide. There are few strategies for the treatment of this disease and the use of thrombolytic tissue plasminogen ...
Z. Vahidinia, M. Karimian, M. Joghataei
semanticscholar +1 more source
Extensive progress has been made to understand the pathophysiology of stroke but it is still a major cause of mortality and disability worldwide. There are few strategies for the treatment of this disease and the use of thrombolytic tissue plasminogen ...
Z. Vahidinia, M. Karimian, M. Joghataei
semanticscholar +1 more source
2001
Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
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Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
openaire +2 more sources
2001
In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
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In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
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Nongenomic effects of neurosteroids
Gynecological Endocrinology, 1998 This review summarizes the current knowledge about the synthesis, the mechanism of action, and the effects of neurosteroids in the central nervous system. Particular attention is paid to the nongenomic actions of neurosteroids, which are discussed in relation to their clinical relevance for physiological and pathological states.
Alberto Revelli, M Massobrio
exaly +4 more sources
International Journal of Molecular Sciences
Peroxisome proliferator-activated receptors (PPARs) may play an important role in the pathomechanism/pathogenesis of Alzheimer’s disease (AD) and several other neurological/neuropsychiatric disorders.
Sylwia Żulińska +2 more
semanticscholar +1 more source
Peroxisome proliferator-activated receptors (PPARs) may play an important role in the pathomechanism/pathogenesis of Alzheimer’s disease (AD) and several other neurological/neuropsychiatric disorders.
Sylwia Żulińska +2 more
semanticscholar +1 more source
Neurosteroids: Biosynthesis and Function
1994The term "neurosteroids" applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the nervous system to levels at least in part independent of steroidogenic gland secretion rates.
P, Robel, E E, Baulieu
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Neurosteroids and status epilepticus
Current Opinion in Endocrine and Metabolic Research, 2022Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has
Gol, Mohammad +2 more
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General and Comparative Endocrinology, 2014
Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
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Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
openaire +2 more sources
Neurosteroids in depression: a review
Psychopharmacology, 2003 A deregulation in concentrations of the neurosteroids (allo)pregnanolone and 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC) has been found in depressed patients. These levels normalize following treatment with selective serotonin reuptake inhibitors (SSRIs).
Broekhoven, F. van, Verkes, R.J.
exaly +5 more sources