Results 181 to 190 of about 12,871 (217)
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Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2019
In this work, a novel strategy of stable isotope labeling derivatization (SILD) combined with magnetic dispersive solid-phase extraction (MDSPE), has been proposed for simultaneous monitoring of neurosteroids changes linked to Parkinson's disease (PD) by
Yanqiu Xu +7 more
semanticscholar +1 more source
In this work, a novel strategy of stable isotope labeling derivatization (SILD) combined with magnetic dispersive solid-phase extraction (MDSPE), has been proposed for simultaneous monitoring of neurosteroids changes linked to Parkinson's disease (PD) by
Yanqiu Xu +7 more
semanticscholar +1 more source
The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells.
Steroids, 2019Glioblastoma (GBM) is the most aggressive local brain tumor and effective treatments are lacking. Many studies have proposed an important participation of steroid hormones in the development of gliomas.
Luis Manuel Pinacho-Garcia +5 more
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Biosynthesis and action of neurosteroids
Brain Research Reviews, 2001Over the past decade, it has become clear that the brain, like the gonad, adrenal and placenta, is a steroidogenic organ. However, unlike classic steroidogenic tissues, the synthesis of steroids in the nervous system requires the coordinate expression and regulation of the genes encoding the steroidogenic enzymes in several different cell types ...
S H, Mellon +2 more
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Neurosteroids: recent findings
Brain Research Reviews, 2001The term neurosteroid applies to those steroids that are synthesized in the nervous system, from cholesterol or other blood-borne steroidal precursors, and that accumulate in the nervous system to levels that are at least in part independent from steroidogenic gland secretion.
E, Plassart-Schiess, E E, Baulieu
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European Archives of Psychiatry and Clinical Neuroscience, 2022
R. Rupprecht +9 more
semanticscholar +1 more source
R. Rupprecht +9 more
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Neurosteroids: Beginning of the story
2001Neurosteroids are synthetisized in the central and the peripheral nervous system, in glial cells, and also in neurons, from cholesterol or steroidal precursors imported from peripheral sources. They include 3 beta-hydroxy-delta 5-compounds, such as pregnenolone (PREG) and dehydroepiandrosterone, their sulfate esters, and compounds known as reduced ...
E E, Baulieu, P, Robel, M, Schumacher
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The Neuropsychopharmacological Potential of Neurosteroids
1999Steroid hormone action involves binding of the steroids to their respective intracellular receptors, which in turn change their conformation by dissociation from the heat-shock proteins, translocate to the nucleus, and there bind to the respective response elements that are located in the regulatory regions of target promoters (1).
Rupprecht, R., Friess, E., Holsboer, F.
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Sheng li ke xue jin zhan [Progress in physiology], 2000
The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
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The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
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Multifaceted Actions of Neurosteroids
ABSTRACT Background and purpose Neurosteroids modulate neuronal function and are promising therapeutic agents for neuropsychiatric disorders. Neurosteroid analogues are approved for treating postpartum depression and are of interest in other disorders.Ajeet Kumar +6 more
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