Results 191 to 200 of about 16,231 (234)

Neuropeptidergic Control of Neurosteroids Biosynthesis.

Frontiers in neuroendocrinology (Print), 2022
Neurosteroids are steroids synthesized within the central nervous system either from cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been suggested that neurosteroids exert pleiotropic activities within the central
T. Ubuka, K. Tsutsui
semanticscholar   +1 more source

Sex Neurosteroids: hormones made by the brain for the brain.

Neuroscience Letters, 2021
In general, hippocampal neurons are capable of synthesizing sex steroids de novo from cholesterol, since the brain is equipped with all the enzymes required for the synthesis of estradiol and testosterone, the end products of sex steroidogenesis ...
L. Fester, G. Rune
semanticscholar   +1 more source

Rapid effects of neurosteroids on neuronal plasticity and their physiological and pathological implications.

Neuroscience Letters, 2021
Current neuroscience research on neurosteroids and their synthetic analogues - neuroactive steroids - clearly demonstrate their drug likeness in a variety of neurological and psychiatric conditions.
E. Kudová
semanticscholar   +1 more source

Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids

World Journal of Biological Psychiatry, 2021
There is increasing evidence that neuroinflammatory processes may play a role in the pathophysiology of psychiatric disorders. Recently, the complement protein C1q and the translocator protein (18 kDa) (TSPO) have attracted considerable interest in this ...
R. Rupprecht, Christian Rupprecht, B. Di Benedetto, G. Rammes   +3 more
semanticscholar   +1 more source

Dehydroepiandrosterone – a neurosteroid

European Journal of Clinical Investigation, 2000
Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells.
Friess, E., Schiffelholz, T., Steckler, T., Steiger, A.   +3 more
openaire   +3 more sources

Neurosteroids and Epileptogenesis

Journal of Neuroendocrinology, 2013
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures occur. This concept has been recently re‐evaluated to include exacerbation of clinically‐manifested epilepsy. Thus, in patients affected by pharmacoresistant seizures, the progression toward a worse condition may be viewed as the result of a durable ...
BIAGINI, Giuseppe, RUSTICHELLI, Cecilia, CURIA, GIULIA, VINET, JONATHAN, LUCCHI, CHIARA, PUGNAGHI, Matteo, MELETTI, Stefano   +6 more
openaire   +4 more sources

Neurosteroid analysis

2001
In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary, R L, Fitzgerald, R H, Purdy   +2 more
openaire   +2 more sources

Neurosteroids and status epilepticus

Current Opinion in Endocrine and Metabolic Research, 2022
Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has
Gol, Mohammad, Lucchi, Chiara, Biagini, Giuseppe   +2 more
openaire   +2 more sources