Results 11 to 20 of about 149,741 (293)

The role of neuroimaging in neurotoxicity after chimeric antigen receptor T-cell therapy [PDF]

Therapeutic Advances in Neurological Disorders
Chimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for several haematological malignancies in relapse and is being evaluated for new indications.
Arian Lasocki, Simon J. Harrison, Michael Dickinson, Tomas Kalincik   +3 more
doaj   +2 more sources

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report [PDF]

Journal of Medical Case Reports
Background Methotrexate is commonly used to treat osteosarcoma and acute lymphoblastic leukemia. Methotrexate can rarely cause neurotoxicity with a wide range of presentations including seizure, hemiparesis, dysarthria, dysphagia, and more.
Olivia L. Makos, Nicole A. Shonka, Kealy M. Marth, Shawna L. Stricker, Mark Keiper, Makayla E. Schissel   +5 more
doaj   +2 more sources

Research Progress on Intervention of Natural Products from Plants in Neurotoxicity of Acrylamide [PDF]

Shipin Kexue, 2023
Acrylamide (ACR) is a common toxic substance in foods, which can cause serious damage to human organs and systems, especially the nervous system. At present, there are no appropriate measures to prevent and treat ACR neurotoxicity.
ZHANG Mengyu, ZHANG Yanqing, FANG Leilei, XIE Junbo, WEI Yinghao
doaj   +1 more source

Kinin B₂ Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Pharmaceuticals, 2023
Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1 ...
Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira   +3 more
doaj   +1 more source

Neuroinflammation in Bilirubin Neurotoxicity

Journal of Integrative Neuroscience, 2023
Bilirubin neurotoxicity is a serious consequence of hyperbilirubinemia, which is the most common disease of the neonatal period. Clinically, bilirubin neurotoxicity can result in motor deficit, auditory dysfunction, cerebral palsy, seizure and ...
Fanhui Zhang, Lihua Chen, Kewen Jiang
doaj   +1 more source

Assessing the association between cefepime percentage free trough level and neurotoxicity

Antimicrobial Stewardship & Healthcare Epidemiology, 2022
Background: Cefepime has a known association with neurotoxicity due to its ability to cross the blood–brain barrier. The symptoms of neurotoxicity are highly variable.
Aleena Zia, Armisha Desai, Molly Tieman, Haley Pritchard   +3 more
doaj   +1 more source

Lithium neurotoxicity [PDF]

Postgraduate Medical Journal, 1979
Summary The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case
P K, Newman, M, Saunders
openaire   +2 more sources

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

Haematologica, 2021
Symptomatic methotrexate-related central neurotoxicity (MTX neurotoxicity) is a severe toxicity experienced during acute lymphoblastic leukemia (ALL) therapy with potential long-term neurologic complications.
Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair   +18 more
doaj   +1 more source

Neurotoxicity by Cefepime: Case-Control Study [PDF]

Journal of Neurocritical Care, 2014
Background: Cefepime is a fourth-generation cephalosporin widely used for empiric treatment of severe infections. Neurotoxicity by cefepime have been reported due to γ-aminobutyric acid A receptor inhibition or other mechanisms. The aim of this study was
Joong Koo Kang, Soon Bae Kim
doaj   +1 more source

Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response

iScience, 2023
Summary: Excessive exposure to manganese (Mn) can cause neurological abnormalities, but the mechanism of Mn neurotoxicity remains unclear. Previous studies have shown that abnormal mitochondrial metabolism is a crucial mechanism underlying Mn ...
Shixuan Zhang, Junrou Zhang, Luli Wu, Li Chen, Piye Niu, Jie Li   +5 more
doaj   +1 more source