Results 11 to 20 of about 33,769 (117)

A new approach on lithium-induced neurotoxicity using rat neuronal cortical culture: Involvement of oxidative stress and lysosomal/mitochondrial toxic Cross-Talk

Main Group Metal Chemistry, 2020
Lithium (Li) is a widely-used medication for the treatment of patients with bipolar disorder. Li causes different complications. One of the most important adverse effects of Li is neurotoxicity.
Yousefsani Bahareh Sadat, Askian Romina, Pourahmad Jalal   +2 more
doaj   +1 more source

Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes on Some Inflammatory Biomarkers in Cadmium Induced Neurotoxicity in Rats

Journal of Toxicology, 2018
Studies have revealed that anti-inflammatory agents could provide beneficial effect in lowering the incidence/progression of neurological diseases. Hence, this study sought to investigate the effect of essential oils from Nigeria ginger and turmeric ...
Ayodele Jacob Akinyemi, Philip Adeyemi Adeniyi   +1 more
doaj   +1 more source

Phase III randomized, placebo‐controlled, double‐blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin‐induced peripheral neurotoxicity in stage II/III colorectal cancer

Cancer Medicine, 2020
Background Monosialotetrahexosylganglioside (GM1) is a neuroprotective glycosphingolipid that repairs nerves. Oxaliplatin‐based chemotherapy is neurotoxic.
De‐shen Wang, Zhi‐qiang Wang, Gong Chen, Jie‐wen Peng, Wei Wang, Yan‐hong Deng, Feng‐hua Wang, Jian‐wei Zhang, Han‐lin Liang, Fen Feng, Chuan‐bo Xie, Chao Ren, Ying Jin, Si‐mei Shi, Wen‐hua Fan, Zhen‐hai Lu, Pei‐rong Ding, Feng Wang, Rui‐hua Xu, Yu‐hong Li   +19 more
doaj   +1 more source

Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia

Antioxidants, 2022
Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer’s disease (AD).
Wataru Araki, Fuyuki Kametani
doaj   +1 more source

Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature

JIMD Reports, 2020
Introduction New neurological symptoms in methylmalonic acidemia (MMA) patients after liver and/or kidney transplantation (LKT) are often described as metabolic stroke‐like‐events.
Femke Molema, Monique Williams, Janneke Langendonk, Sarwa Darwish‐Murad, Jacqueline van deWetering, Ed Jacobs, Willem Onkenhout, Esther Brusse, Anke van derEerden, Margreet Wagenmakers   +9 more
doaj   +1 more source

Cross-Neutralisation of In Vitro Neurotoxicity of Asian and Australian Snake Neurotoxins and Venoms by Different Antivenoms

Toxins, 2016
There is limited information on the cross-neutralisation of neurotoxic venoms with antivenoms. Cross-neutralisation of the in vitro neurotoxicity of four Asian and four Australian snake venoms, four post-synaptic neurotoxins (α-bungarotoxin, α-elapitoxin-
Anjana Silva, Wayne C. Hodgson, Geoffrey K. Isbister   +2 more
doaj   +1 more source

A case of spinal nerve neurotoxicity with ropivacaine after combined spinal and epidural anesthesia

JA Clinical Reports, 2021
Background Neurotoxicity caused by a local anesthetic after regional anesthesia is a rare but serious problem for anesthesiologists. It is difficult to diagnose neurotoxicity from anesthetics because of the large number of possible diagnoses.
Tsukasa Shimauchi, Jun Yoshino, Naoyuki Fujimura   +2 more
doaj   +1 more source

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Frontiers in Genetics, 2021
Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li, Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic, Anze Zupanic   +9 more
doaj   +1 more source

Central neurotoxicity of immunomodulatory drugs in multiple myeloma

Hematology Reports, 2015
Immunomodulatory drugs (IMiDs) currently used in the treatment of multiple myeloma, are thalidomide, lenalidomide and pomalidomide. One of the most common side effects of thalidomide is neurotoxicity, predominantly in the form of peripheral neuropathy ...
Urmeel H. Patel, Muhammad A. Mir, Jeffrey K. Sivik, Divisha Raheja, Manoj K. Pandey, Giampaolo Talamo   +5 more
doaj   +1 more source

Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity

Toxics, 2023
Chemotherapy-induced peripheral neurotoxicity is one of the most common dose-limiting toxicities of several widely used anticancer drugs such as platinum derivatives (cisplatin) and taxanes (paclitaxel).
Eleonora Pozzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Mario Bossi, Paola Alberti, Alessio Malacrida, Cristina Meregalli, Arianna Scuteri, Guido Cavaletti, Valentina Alda Carozzi   +12 more
doaj   +1 more source