Results 21 to 30 of about 33,769 (117)
Machine Learning to Predict Developmental Neurotoxicity with High-throughput Data from 2D Bio-engineered Tissues [PDF]
, 2019 There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from challenges related to time, cost, and applicability to human physiology.
arxiv +1 more source
Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age [PDF]
arXiv, 2023 For the first time in the world behavioral functions of laboratory mammals exposed to silver nanoparticles were studied with the regard to age. Silver nanoparticles coated with polyvinylpyrrolidone with the size of 8.7 nm were used in the present research as a potential xcenobiotic.
arxiv
Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins [PDF]
Molecular BioSystems 2016: 12 (9), 2700-2712, 2016 Knots in proteins have been proposed to resist proteasomal degradation. Ample evidence associates proteasomal degradation with neurodegeneration. One interesting possibility is that indeed knotted conformers stall this machinery leading to toxicity. However, although the proteasome is known to unfold mechanically its substrates, at present there are no
arxiv +1 more source
Cancer Medicine, 2020 Objectives The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phase II randomized ...
Laurie E. Steffen McLouth +14 more
doaj +1 more source
Characterization of Phosphorylated Tau-Microtubule complex with Molecular Dynamics (MD) simulation [PDF]
arXiv, 2023 Alzheimer's Disease (AD), a neurodegenerative disorder, is reported as one of the most severe health and socioeconomic problems in current public health. Tau proteins are assumed to be a crucial driving factor of AD that detach from microtubules (MT) and accumulate as neurotoxic aggregates in the brains of AD patients.
arxiv
Non-neurotoxic Nanodiamond Probes for Intraneuronal Temperature Mapping [PDF]
ACS Nano 11, 12077, 2017, 2018 Optical bio-markers have been used extensively for intracellular imaging with high spatial and temporal resolution. Extending the modality of these probes is a key driver in cell biology. In recent years, the NV centre in nanodiamond has emerged as a promising candidate for bio-imaging and bio-sensing with low cytotoxicity and stable photoluminescence.
arxiv +1 more source
iScience, 2023 Summary: Excessive exposure to manganese (Mn) can cause neurological abnormalities, but the mechanism of Mn neurotoxicity remains unclear. Previous studies have shown that abnormal mitochondrial metabolism is a crucial mechanism underlying Mn ...
Shixuan Zhang +5 more
doaj
Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy
Biomarker Research, 2018 Severe cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T cell (CAR-T) therapy can be life-threatening in some cases, and management of those toxicities is still a great challenge for physicians.
Zhenguang Wang, Weidong Han
doaj +1 more source
Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity
Frontiers in Pharmacology, 2023 Background: An increasing number of studies have reported that neurotoxicity of propofol may cause long-term learning and cognitive dysfunction. Hypoxic preconditioning has been shown to have neuroprotective effects, reducing the neurotoxicity of ...
Jing Chen +8 more
doaj +1 more source
Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights. [PDF]
PLoS ONE, 2017 Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic severe sensory peripheral neuropathy.
Paola Marmiroli +16 more
doaj +1 more source