Results 31 to 40 of about 149,741 (293)

Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature

JIMD Reports, 2020
Introduction New neurological symptoms in methylmalonic acidemia (MMA) patients after liver and/or kidney transplantation (LKT) are often described as metabolic stroke‐like‐events.
Femke Molema, Monique Williams, Janneke Langendonk, Sarwa Darwish‐Murad, Jacqueline van deWetering, Ed Jacobs, Willem Onkenhout, Esther Brusse, Anke van derEerden, Margreet Wagenmakers   +9 more
doaj   +1 more source

Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia

Antioxidants, 2022
Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer’s disease (AD).
Wataru Araki, Fuyuki Kametani
doaj   +1 more source

A case of spinal nerve neurotoxicity with ropivacaine after combined spinal and epidural anesthesia

JA Clinical Reports, 2021
Background Neurotoxicity caused by a local anesthetic after regional anesthesia is a rare but serious problem for anesthesiologists. It is difficult to diagnose neurotoxicity from anesthetics because of the large number of possible diagnoses.
Tsukasa Shimauchi, Jun Yoshino, Naoyuki Fujimura   +2 more
doaj   +1 more source

Cross-Neutralisation of In Vitro Neurotoxicity of Asian and Australian Snake Neurotoxins and Venoms by Different Antivenoms

Toxins, 2016
There is limited information on the cross-neutralisation of neurotoxic venoms with antivenoms. Cross-neutralisation of the in vitro neurotoxicity of four Asian and four Australian snake venoms, four post-synaptic neurotoxins (α-bungarotoxin, α-elapitoxin-
Anjana Silva, Wayne C. Hodgson, Geoffrey K. Isbister   +2 more
doaj   +1 more source

Central neurotoxicity of immunomodulatory drugs in multiple myeloma

Hematology Reports, 2015
Immunomodulatory drugs (IMiDs) currently used in the treatment of multiple myeloma, are thalidomide, lenalidomide and pomalidomide. One of the most common side effects of thalidomide is neurotoxicity, predominantly in the form of peripheral neuropathy ...
Urmeel H. Patel, Muhammad A. Mir, Jeffrey K. Sivik, Divisha Raheja, Manoj K. Pandey, Giampaolo Talamo   +5 more
doaj   +1 more source

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Frontiers in Genetics, 2021
Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li, Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic, Anze Zupanic   +9 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity

Frontiers in Pharmacology, 2023
Background: An increasing number of studies have reported that neurotoxicity of propofol may cause long-term learning and cognitive dysfunction. Hypoxic preconditioning has been shown to have neuroprotective effects, reducing the neurotoxicity of ...
Jing Chen, Fei Xiao, Lifei Chen, Zhan Zhou, Yi Wei, Yu Zhong, Li Li, Yubo Xie, Yubo Xie   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Patient‐reported tolerability of veliparib combined with cisplatin and etoposide for treatment of extensive stage small cell lung cancer: Neurotoxicity and adherence data from the ECOG ACRIN cancer research group E2511 phase II randomized trial

Cancer Medicine, 2020
Objectives The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phase II randomized ...
Laurie E. Steffen McLouth, Fengmin Zhao, Taofeek K. Owonikoko, Josephine L. Feliciano, Nisha A. Mohindra, Suzanne E. Dahlberg, James L. Wade III, Gordan Srkalovic, Bradley W. Lash, Joseph W. Leach, Ticiana A. Leal, Charu Aggarwal, David Cella, Suresh S. Ramalingam, Lynne I. Wagner   +14 more
doaj   +1 more source