Results 31 to 40 of about 33,769 (117)
Causes of Antiepileptic Treatment Failure
Pediatric Neurology Briefs, 1987 The Veterans Administration Epilepsy Cooperative Study Group (Regional Epilepsy Center, VA Med Cntr, 4500 S Lancaster Rd, Dallas, TX) have evaluated monotherapy with carbamazepine, phenobarbital, phenytoin, and primidone in a total of 622 patients with ...
J Gordon Millichap
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Modeling Amyloid Beta Peptide Insertion into Lipid Bilayers [PDF]
, 2003 Inspired by recent suggestions that the Alzheimer's amyloid beta peptide (A beta) can insert into cell membranes and form harmful ion channels, we model insertion of the 40 and 42 residue forms of the peptide into cell membranes using a Monte Carlo code which is specific at the amino acid level.
arxiv +1 more source
Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity
Toxics, 2015 Peripheral neurotoxicity is the dose-limiting factor for clinical use of platinum derivatives, a class of anticancer drugs which includes cisplatin, carboplatin, and oxaliplatin.
Alessia Chiorazzi +2 more
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The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection
Frontiers in ToxicologyIAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, the role and mechanism of IAA neurotoxicity remain unclear.
Xu Wang +11 more
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Methylmercury toxic mechanism related to protein degradation and chemokine transcription
Environmental Health and Preventive Medicine, 2020 Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate ...
Jin-Yong Lee +3 more
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Molecules, 2021 Methamphetamine (METH) is a synthetic psychostimulant drug that has detrimental effects on the health of its users. Although it has been investigated as a cause of neurodegenerative disease due to its neurotoxicity, whether small molecules derived from ...
Hyun-Su Lee, Gil-Saeng Jeong
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Molecular Therapy: Nucleic Acids, 2023 Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations.
Chunyan Jia +7 more
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A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases [PDF]
, 2015 The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments align longitudinally in axons and are interspersed in axonal cross-sections.
arxiv +1 more source
Majalah Kedokteran BandungIncreased use of pesticides can have detrimental health consequences, one of which is chronic neurotoxicity. The symptoms include degenerative and neurobehavioral issues.
Muhammad Ihwan Narwanto +6 more
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Molecules, 2017 Spirulina maxima is a microalgae which contains flavonoids and other polyphenols. Although Spirulina maxima 70% ethanol extract (SM70EE) has diverse beneficial effects, its effects on neurotoxicity have not been fully understood.
Eun-Jeong Koh +6 more
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