Results 61 to 70 of about 25,999 (347)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Attenuation of acrylamide-induced neurotoxicity by supplementation of sitagliptin in Wistar rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Acrylamide (ACR) induces neurotoxicity in humans and animals through different mechanisms. Sitagliptin is a type-2 diabetes medication with neuroprotective properties.
Mahboobeh Navabi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh   +3 more
doaj   +1 more source

Early postoperative seizures in liver and kidney recipients

Вестник трансплантологии и искусственных органов, 2021
Background. Transplantation is presently the only treatment for end-stage liver and kidney failure. Up to 42% of liver transplant recipients and up to 30% of kidney transplant recipients have neurological complications from the transplantation.
O. M. Tsirulnikova, A. V. Syrkina, I. A. Miloserdov, I. E. Pashkova, S. Yu. Oleshkevich, I. B. Komarova   +5 more
doaj   +1 more source

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism [PDF]

, 2013
Peer reviewedPublisher ...
Calignano, A, D'Agostino, G, Di Cesare Mannelli, L, Ghelardini, C, Pacini, A, Russo, R, Zanardelli, M   +6 more
core   +4 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions [PDF]

, 2017
Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists.
Adams, Alberti, Andersen, Arcidiacono Paolo, Argyriou, Bae, Bagi, Bapat, Bhatnagar, Bianchi, Bickels, Bilinska, Binda, Boland, Bond-Smith, Boyette-Davis, Boyette-Davis, Boyette-Davis, Brant, Breivik, Brian Schmidt, Bruehl, Buga, Burakgazi, Callstrom, Caraceni, Caraceni, Caraceni, Caraceni, Carla, Cata, Cavaletti, Cavaletti, Cavaletti, Cavaletti, Cavaletti, Cavaletti, Cavaletti, Cetin, Chartier, Chen, Cheng, Chow, Chow, Chow, Christine Miaskowski, Clark, Cleeland, Clemons, Coleman, Coleman, Conti, Cook, Coombes, de Carvalho Barbosa, Delaney, Demir, Donovan, Dougherty, Dubey, Dworkin, Edwards, Falk, Farquhar-Smith, Farrell, Fasanella, Fillingim, Flatters, Freeman, Geber, Golan-Vered, Gordon-Williams, Gough, Gralow, Grant, Griffiths, Hage, Halabi, Han, Hausheer, Herdon, Hershman, Hershman, Hertz, Hong, Isakoff, Janjan, Johanes, John T. Farrar, Judith A. Paice, Kagohashi, Kirou-Mauro, Klein, Krech, Kurosaka, Laird, Lam, Lam, Langford, Lewis, Li, Li, Liberati, Maixner, Malik, Mantyh, Mantyh, Massey, Matt Mulvey, McCaffrey, Mendoza, Mercadante, Miaskowski, Michael Bennett, Mick, Mieog, Miltenburg, Mitera, Montgomery, Moreau, Mulvey, Nahman-Averbuch, Niu, Nomiya, Nudelman, Pachman, Paice, Park, Patrick M. Dougherty, Patrick W. Mantyh, Phillips, Pignataro, Pollen, Portenoy, Portenoy, Reddy, Reyes-Gibby, Riccio, Richardson, Rizzoli, Rodionov, Rustoen, Rykowski, Ryo, Sansur, Schmidt, Schmidt, Scott, Seretny, Sestak, Sharma, Siegel, Silverman, Slosky, Stubblefield, Taverner, Tersmette, Themistocleous, Thomas J. Smith, Tofthagen, Toyama, Treede, Trinkaus, Turk, Vardeh, Ventzel, Vichaya, Wilson, Wong, Yang, Zedan   +170 more
core   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

From CAR-T Cells to CAR-NK Cells: A Developing Immunotherapy Method for Hematological Malignancies

Frontiers in Oncology, 2021
The approval of CD19 chimeric antigen receptor (CAR)-engineered T (CAR-T) cell products in B-cell malignancies represents a breakthrough in CAR-T cell immunotherapy.
Hui Lu, Xiaoyan Zhao, Ziying Li, Yu Hu, Huafang Wang   +4 more
doaj   +1 more source

Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS) [PDF]

, 2022
Marc Wehrli, Kathleen Gallagher, Yi‐Bin Chen, Mark B. Leick, Steven L. McAfee, Areej El‐Jawahri, Zachariah DeFilipp, Nora Horick, Paul V. O’Donnell, Thomas R. Spitzer, Bimal Dey, Daniella Cook, Michael Trailor, Kevin Lindell, Marcela V. Maus, Matthew J. Frigault   +15 more
openalex   +1 more source

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source