Results 151 to 160 of about 65,558 (345)
Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system. [PDF]
, 1979 Nobutaka Hirokawa, Masaru Kitamura
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei +4 more
wiley +1 more source
Using the Honey Bee (Apis mellifera L.) Cell Line AmE‐711 to Evaluate Insecticide Toxicity
Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 88-99, January 2023., 2023 Abstract One of the main contributors to poor productivity and elevated mortality of honey bee colonies globally is insecticide exposure. Whole‐organism and colony‐level studies have demonstrated the effects of insecticides on many aspects of honey bee biology and have also shown their interactions with pathogens.
Michael Goblirsch, John J. Adamczyk
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang +5 more
wiley +1 more source
Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 71-87, January 2023., 2023 Abstract For the majority of developed adverse outcome pathways (AOPs), the taxonomic domain of applicability (tDOA) is typically narrowly defined with a single or a handful of species. Defining the tDOA of an AOP is critical for use in regulatory decision‐making, particularly when considering protection of untested species.
Marissa A. Jensen +2 more
wiley +1 more source
Behaviour of Paramecium aurelia in Solutions of Purified and Fluorescent Labelled Tetanus Neurotoxin
, 1966 Sumner I. Zacks, Michael F. Sheff
openalex +1 more source
Annals of Neurology, EarlyView.Objective The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted in less decline on measures of cognition and function than placebo. Herein, we aimed to characterize amyloid‐β (Aβ) protofibril (PF) captured by lecanemab in human cerebrospinal fluid (CSF) from living participants with ...
Moeko Noguchi‐Shinohara +8 more
wiley +1 more source
Annals of Neurology, EarlyView.At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard +22 more
wiley +1 more source