Results 11 to 20 of about 105,668 (383)

On Botulinum Neurotoxin Variability [PDF]

open access: yesmBio, 2015
The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this
C. Montecucco, M. Rasotto
semanticscholar   +6 more sources

Comparison of botulinum neurotoxin type A formulations in Asia

open access: yesClinical, Cosmetic and Investigational Dermatology, 2018
Jürgen Frevert,1 Ki Young Ahn,2 Mee Young Park,3 Owen Sunga4 1Merz Pharmaceuticals GmbH, Frankfurt, Germany; 2Dr. Ahn’s Plastic and Aesthetic Surgical Clinic, Daegu, South Korea; 3Department of Neurology, Yeungnam University School of Medicine,
Frevert J, Ahn KY, Park MY, Sunga O
doaj   +2 more sources

Neurotoxin: Durable Backdoors in Federated Learning [PDF]

open access: yesInternational Conference on Machine Learning, 2022
Due to their decentralized nature, federated learning (FL) systems have an inherent vulnerability during their training to adversarial backdoor attacks.
Zhengming Zhang   +7 more
semanticscholar   +1 more source

Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines

open access: yesToxins, 2022
Botulinum neurotoxin injection for treating glabellar frown lines is a commonly used method; however, side effects, such as ptosis and samurai eyebrow, have been reported due to a lack of comprehensive anatomical knowledge.
Kyu-Ho Yi   +3 more
semanticscholar   +1 more source

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

open access: yesNature Communications, 2022
Bites by elapid snakes (e.g. cobras) can result in life-threatening paralysis caused by venom neurotoxins blocking neuromuscular nicotinic acetylcholine receptors.
Mieke Nys   +10 more
semanticscholar   +1 more source

Anatomical Proposal for Botulinum Neurotoxin Injection Targeting the Platysma Muscle for Treating Platysmal Band and Jawline Lifting: A Review

open access: yesToxins, 2022
The platysma muscle is a thin superficial muscle that covers the entire neck and lower part of the face. The platysma muscle is the primary target muscle for botulinum neurotoxin injection therapy aimed at treating platysmal band and lower facial lifting.
Kyu-Ho Yi   +5 more
semanticscholar   +1 more source

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

open access: yesScience, 2021
A lethal combination Although many human activities have clear negative effects on the natural world, there are also unforeseen consequences. Bald eagle mass death events in the southeastern United States may be one such downstream effect of human ...
S. Breinlinger   +20 more
semanticscholar   +1 more source

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity

open access: yesScience, 2021
Moving targets of neurotoxins Proteases that cleave protein targets at specific sequences control many biological functions. The ability to reprogram proteases to cleave new sequences of our choosing would enable new therapeutic and biotechnological ...
T. Blum   +10 more
semanticscholar   +1 more source

Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets

open access: yesJournal of Neurochemistry, 2021
Tetanus is a deadly but preventable disease caused by a protein neurotoxin produced by Clostridium tetani. Spores of C. tetani may contaminate a necrotic wound and germinate into a vegetative bacterium that releases a toxin, termed tetanus neurotoxin ...
A. Megighian   +4 more
semanticscholar   +1 more source

Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson’s Disease

open access: yesFrontiers in Aging Neuroscience, 2022
BackgroundExercise plays an essential role in improving motor symptoms in Parkinson’s disease (PD), but the underlying mechanism in the central nervous system remains unclear.MethodsMotor ability was observed after 12-week treadmill exercise on a 1 ...
Weifang Tong   +12 more
doaj   +1 more source

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