Results 31 to 40 of about 70,461 (257)

Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature [PDF]

, 2017
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which ...
Marco Pirazzini, Peck, Michael,, Carolina Lúquez, Kalb, Suzanne R., Karen K. Hill, Dorner, Brigitte, G, Florigio Lista, Lúquez, Carolina, Theresa Smith, Kalb, Suzanne,, Michel R. Popoff, Michel Popoff, Paula Cuervo, Yagmur Derman, Brigitte Dorner, Cuervo, Paula, Sandra C. Stringer, Karen Hill, Cheng, Luisa, W, Hill, Karen,, Mazuet, Christelle, Dorner, Brigitte G., Bradshaw, Marite, Luisa Cheng, Sandra Stringer, Cheng, Luisa W., Kalb, Suzanne, R, Andreas Rummel, Luca Bano, Singh, Bal, Stringer, Sandra,, Fisher, Audrey, Dorner, Brigitte,, PIRAZZINI, MARCO, Stringer, Sandra C., Hill, Karen K., Lista, Florigio, Popoff, Michel, Miia Lindström, Christelle Mazuet, Audrey Fisher, Suzanne Kalb, Popoff, Michel R., Hill, Karen, K, Bal Singh, Hannu Korkeala, Marite Bradshaw, Theresa J. Smith, Lúquez, Carolina, Luisa W. Cheng, Dorner, Brigitte, ROSSETTO, ORNELLA, Derman, Yagmur, Fabrizio Anniballi, Austin, John, Sesardic, Dorothea, Peck, Michael W, Korkeala, Hannu, Bal Ram Singh, Smith, Theresa J., Lindström, Miia, Austin, John W., Stringer, Sandra, C, Smith, Theresa,, Rummel, Andreas, Dorothea Sesardic, Suzanne R. Kalb, Lindström, Miia, Michael W. Peck, Peck, Michael, W, John Austin, Bano, Luca, John W. Austin, Anniballi, Fabrizio, Peck, Michael W., Smith, Theresa, J, Brigitte G. Dorner, Ornella Rossetto, Michael Peck, Singh, Bal Ram, Cheng, Luisa,   +80 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

, 2010
A droplet-based microfluidic device integrated with a novel floatage-based trap array and a tapered immobilization channel array was presented for characterizing the neurotoxin-induced multiple responses in individual Caenorhabditis elegans (C.
Qin, Jianhua, 林炳承, Shi, Yang, Wen, Hui, Shi, Weiwei, Lu, Yao, Lin, Bingcheng, 秦建华   +7 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans

, 2009
The soil dwelling nematode Caenorhabditis elegans (C. elegans) is an excellent model organism for the study of numerous disease including neurodegenerative disease.
Qin, Jianhua, 林炳承, Weiwei Shi, Ma, Hui, Hui Ma, Shi, Weiwei, Bingcheng Lin, Jiang, Lei, Lei Jiang, Jianhua Qin, Lin, Bingcheng, 秦建华   +11 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Identification of a precursor processing protease from the spider Cupiennius salei essential for venom neurotoxin maturation. [PDF]

, 2018
Spider venom neurotoxins and cytolytic peptides are expressed as elongated precursor peptides, which are post-translationally processed by proteases to yield the active mature peptides.
Wolfgang Nentwig, Langenegger, Nicolas, Stefan Schürch, Lucia Kuhn-Nentwig, Kuhn-Nentwig, Lucia, Dominique Koua, Schürch, Stefan, Manfred Heller, Nicolas Langenegger, Heller, Manfred, Koua, Dominique, Nentwig, Wolfgang   +11 more
core   +2 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Use of Botulinum Neurotoxin in Ophthalmology

, 2016
Botulinum neurotoxin (BoNT) is the first biological toxin used in the treatment of ophthalmic diseases and to decrease skin wrinkles as an aesthetic agent.
Basar, Emel, Arici, Ceyhun, Ceyhun Arıcı, Emel Başar   +3 more
core   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source