Results 31 to 40 of about 57,926 (263)

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson’s disease model

Frontiers in Pharmacology, 2023
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the development, maintenance and survival of neurons. This study aims to localize NT3-expressing cells in the adult zebrafish brain and examine the role of NT3 in a ...
Noor Azzizah Omar, Noor Azzizah Omar, Jaya Kumar, Seong Lin Teoh   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conflicting Clinical Presentation of Infection with Clostridium botulinum and Clostridium perfringens in a 5-Month-Old Infant

Journal of Pediatrics: Clinical Practice
We present a 5-month-old infant with a 1-day history of poor feeding and sudden progression into generalized weakness including septic shock syndrome after consumption of homemade food. Botulism and sepsis symptoms could be explained by the presence of a
Barbara Schaub, MD, Carolyn Luhman-Lunt, MD, Andrea Ott, MD, Maren Krüger, DSc, Martin Skiba, PhD, Sylvia Worbs, PhD, Brigitte G. Dorner, PhD, Michael Buettcher, MD, Martin B. Dorner, PhD   +8 more
doaj   +1 more source

Evaluation and Optimization of Microdrop Digital PCR for Detection of Serotype A and B Clostridium botulinum

Frontiers in Microbiology, 2022
Clostridium botulinum is the causative pathogen of botulism. Laboratory detection of C. botulinum is essential for clinical therapy treatment of botulism due to the difficulty in diagnosis, especially in infant botulism. The extreme toxicity of botulinum
Pengya Gao, Pengya Gao, Changde Wu, Jin Zhang, Shuping Wang, Ying Huang, Yinping Dong, Tingting Liu, Changyun Ye, Xuefang Xu, Wenwen Xin   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Electrical or magnetic nerve stimulation enhance the BoNT/A-mediated muscle paralysis

Journal of NeuroEngineering and Rehabilitation
Background Botulinum toxin type A (BoNT/A) is first-line treatment for muscle spasticity but the dose can be limited by side effects depending on the treated muscle mass and location.
Stefanie Honndorf, Klaus Fink
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Evaluation of a neurotoxin as an adjunctive treatment modality for the management of gummy smile

Indian Dermatology Online Journal, 2019
Introduction: Excessive gingival display while smiling mars facial aesthetics, this condition is referred to as “gummy smile” (GS). Available literature suggests that Botulinum toxin type A (BTX-A) is effective in the management of excessive gingival ...
Neha Gupta, Sarvraj Kohli
doaj   +1 more source

Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment

Toxins, 2023
Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler, Michael Abouyannis, Ashish Bhalla, Matthew R. Lewin   +3 more
doaj   +1 more source

Botulinum and Tetanus Neurotoxins

Annual Review of Biochemistry, 2019
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Dong, Min, Masuyer, Geoffrey, Stenmark, Pål   +2 more
openaire   +4 more sources