Results 51 to 60 of about 90,679 (311)
Electrical or magnetic nerve stimulation enhance the BoNT/A-mediated muscle paralysis
Journal of NeuroEngineering and RehabilitationBackground Botulinum toxin type A (BoNT/A) is first-line treatment for muscle spasticity but the dose can be limited by side effects depending on the treated muscle mass and location.
Stefanie Honndorf, Klaus Fink
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Botulinum and Tetanus Neurotoxins
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Dong, Min +2 more
openaire +4 more sources
Toxins, 2023 Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler +3 more
doaj +1 more source
Identification of a botulinum neurotoxin-like toxin in a commensal strain of Enterococcus faecium
Cell Host and Microbe, 2018 Summary Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents.
Sicai Zhang +12 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Evaluation of a neurotoxin as an adjunctive treatment modality for the management of gummy smile
Indian Dermatology Online Journal, 2019 Introduction: Excessive gingival display while smiling mars facial aesthetics, this condition is referred to as “gummy smile” (GS). Available literature suggests that Botulinum toxin type A (BTX-A) is effective in the management of excessive gingival ...
Neha Gupta, Sarvraj Kohli
doaj +1 more source
BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves
Toxins, 2022 Botulinum neurotoxin (BoNT/A) is an FDA and NICE approved second-line treatment for overactive bladder (OAB) in patients either not responsive or intolerant to anti-cholinergic drugs.
Hodan Ibrahim +4 more
doaj +1 more source
Identification of a novel botulinum neurotoxin gene cluster in Enterococcus
FEBS Letters, 2018 The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A–G; X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an operon containing an ntnh gene upstream of the boNT gene.
J. Brunt +3 more
semanticscholar +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source