Results 71 to 80 of about 90,679 (311)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
New Neurotoxins on the Horizon [PDF]
Aesthetic Surgery Journal, 2008 Toxins isolated from lethal bacteria allow for safe, versatile, and minimally invasive interventions that have revolutionized the field of cosmetic and therapeutic treatments. Botulinum toxins are high-molecular weight proteins produced by Gram-positive, spore-forming Clostridial bacteria.
Scott R, Freeman, Joel L, Cohen
openaire +2 more sources
ToxinsThis retrospective, observational study describes the clinical findings, case management trends, and outcomes of 83 dogs and nine cats exposed to eastern coral snakes in a university teaching hospital setting.
Jordan M. Sullivan +3 more
doaj +1 more source
Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins
Marine Drugs, 2012 Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products.
John Pablo +5 more
doaj +1 more source
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
Nature Communications, 2017 Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue ...
Liang Tao +12 more
semanticscholar +1 more source
Advanced Engineering Materials, EarlyView.This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele +2 more
wiley +1 more source
Utilities of Botulinum Toxins in Dermatology and Cosmetology
Clinical, Cosmetic and Investigational Dermatology, 2021 Piyu Parth Naik Department of Dermatology, Saudi German Hospital and Clinic, Dubai, United Arab EmiratesCorrespondence: Piyu Parth NaikDepartment of Dermatology, Saudi German Hospital and Clinic, Opposite Burj Al Arab, Dubai, United Arab EmiratesTel +971
Naik PP
doaj
Advanced Functional Materials, EarlyView.A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu +8 more
wiley +1 more source
Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats
Advanced Functional Materials, EarlyView.We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang +18 more
wiley +1 more source