Results 61 to 70 of about 96,331 (301)

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R, Conrad, Fraser, Espinoza, Yero, Garcia-Rodriguez, Consuelo, Kimbler, Angie, Kraus, Carl N, Marks, James D, Martinez, Zachary, Pham, Khanh, Riling, Kathryn, Snow, Doris M, Tomic, Milan T, Wong, David   +12 more
core  

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Toxins, 2018
Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV).
Daniel Oliveira da Mata, Diogo Vieira Tibery, Leandro Ambrósio Campos, Thalita Soares Camargos, Steve Peigneur, Jan Tytgat, Elisabeth Ferroni Schwartz   +6 more
doaj   +1 more source

Exploring the genetic background of the botulism neurotoxin BoNT/B2 in Spain

Microbiology Spectrum, 2023
To determine whether the neurotoxin BoNT/B2 causing botulism in Spain is clonal, the genetic diversity and phylogenetic relationships of Clostridium botulinum from food-borne episodes and infant cases of the condition were explored.
Sylvia Valdezate, Gema Carrasco, María J. Medina, Noelia Garrido, Silvia del Pino, Monica Valiente, María P. Pallarés, Pilar Villalon   +7 more
doaj   +1 more source

Methylmercury varies more than one order of magnitude in commercial European rice [PDF]

, 2017
P.M. thanks the Royal Thai Government for funding and C.C.B.
Brombach, Christoph-Cornelius, Chen, Bin, Corns, Warren T, Ezzeldin, Mohamed Farouk, Feldmann, Jorg, Kolambage-Dona, Piumi P.P., Krupp, Eva Maria, Manorut, Parinda   +7 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Retrospective Evaluation of Clinical and Clinicopathologic Findings, Case Management, and Outcome for Dogs and Cats Exposed to Micrurus fulvius (Eastern Coral Snake): 92 Cases (2021–2022)

Toxins
This retrospective, observational study describes the clinical findings, case management trends, and outcomes of 83 dogs and nine cats exposed to eastern coral snakes in a university teaching hospital setting.
Jordan M. Sullivan, Taelor L. Aasen, Corey J. Fisher, Michael Schaer   +3 more
doaj   +1 more source

Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins

Marine Drugs, 2012
Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products.
John Pablo, Deborah C. Mash, Sandra A. Banack, Neil Hammerschlag, Margaret Basile, Kiyo Mondo   +5 more
doaj   +1 more source