Results 41 to 50 of about 90,679 (311)

Short Toxin-like Proteins Attack the Defense Line of Innate Immunity

Toxins, 2013
ClanTox (classifier of animal toxins) was developed for identifying toxin-like candidates from complete proteomes. Searching mammalian proteomes for short toxin-like proteins (coined TOLIPs) revealed a number of overlooked secreted short proteins with an
Tsiona Eliyahu, Michal Linial, Yitshak Tirosh, Dan Ofer   +3 more
doaj   +1 more source

Wintersweet (Chimonanthus praecox) toxicity in 5 sheep

Journal of Veterinary Internal Medicine, 2023
Two sheep presented with acute tonic‐clonic seizures, opisthotonos, absent pupillary light reflexes and abnormal vital signs within 18 hours after observed consumption of leaves from an ornamental shrub later identified as wintersweet (Chimonanthus ...
Cambrey Knapp, Thomas Van Dyke, Derek Foster   +2 more
doaj   +1 more source

Therapy of Sialorrhea with Botulinum Neurotoxin

Neurological Therapeutics, 2019
Botulinum neurotoxin (BoNT) is considered the treatment of choice for various symptoms and diseases such as focal dystonia and focal spasticity. The effects of BoNT on the salivary glands have also been known for years, but their use was limited because ...
W. Jost, T. Bäumer, R. Laskawi, J. Sławek, Björn Spittau, A. Steffen, M. Winterholler, G. Bavikatte   +7 more
semanticscholar   +1 more source

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson’s disease model

Frontiers in Pharmacology, 2023
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the development, maintenance and survival of neurons. This study aims to localize NT3-expressing cells in the adult zebrafish brain and examine the role of NT3 in a ...
Noor Azzizah Omar, Noor Azzizah Omar, Jaya Kumar, Seong Lin Teoh   +3 more
doaj   +1 more source

Neurotoxin and Alpha-Neurotoxin Time-Resolved Absorption and Resonance FT-IR and Raman Bio spectroscopy and Density Functional Theory (DFT) Investigation of Vibrionic-Mode Coupling Structure in Vibrational Spectra Analysis

American Journal of Biomedical Science & Research, 2019
α-Neurotoxins are a group of neurotoxic peptides found in the venom of snakes in the families Elapidae and Hydrophiidae. They can cause paralysis, respiratory failure, and death.
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conflicting Clinical Presentation of Infection with Clostridium botulinum and Clostridium perfringens in a 5-Month-Old Infant

Journal of Pediatrics: Clinical Practice
We present a 5-month-old infant with a 1-day history of poor feeding and sudden progression into generalized weakness including septic shock syndrome after consumption of homemade food. Botulism and sepsis symptoms could be explained by the presence of a
Barbara Schaub, MD, Carolyn Luhman-Lunt, MD, Andrea Ott, MD, Maren Krüger, DSc, Martin Skiba, PhD, Sylvia Worbs, PhD, Brigitte G. Dorner, PhD, Michael Buettcher, MD, Martin B. Dorner, PhD   +8 more
doaj   +1 more source

Evaluation and Optimization of Microdrop Digital PCR for Detection of Serotype A and B Clostridium botulinum

Frontiers in Microbiology, 2022
Clostridium botulinum is the causative pathogen of botulism. Laboratory detection of C. botulinum is essential for clinical therapy treatment of botulism due to the difficulty in diagnosis, especially in infant botulism. The extreme toxicity of botulinum
Pengya Gao, Pengya Gao, Changde Wu, Jin Zhang, Shuping Wang, Ying Huang, Yinping Dong, Tingting Liu, Changyun Ye, Xuefang Xu, Wenwen Xin   +10 more
doaj   +1 more source

Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae

Biomedicines, 2019
Neurotoxin exposure of zebrafish larvae has been used to mimic a Parkinson’s disease (PD) phenotype and to facilitate high-throughput drug screening. However, the vulnerability of zebrafish to various neurotoxins was shown to be variable.
Michael Kalyn, Khang Hua, Suzita Mohd Noor, Chee Ern David Wong, M. Ekker   +4 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source