Results 71 to 80 of about 132,798 (382)
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins
Marine Drugs, 2012 Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products.
John Pablo +5 more
doaj +1 more source
Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]
, 2008 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE +5 more
core +1 more source
Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae
Biomedicines, 2019 Neurotoxin exposure of zebrafish larvae has been used to mimic a Parkinson’s disease (PD) phenotype and to facilitate high-throughput drug screening. However, the vulnerability of zebrafish to various neurotoxins was shown to be variable.
Michael Kalyn +4 more
semanticscholar +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Utilities of Botulinum Toxins in Dermatology and Cosmetology
Clinical, Cosmetic and Investigational Dermatology, 2021 Piyu Parth Naik Department of Dermatology, Saudi German Hospital and Clinic, Dubai, United Arab EmiratesCorrespondence: Piyu Parth NaikDepartment of Dermatology, Saudi German Hospital and Clinic, Opposite Burj Al Arab, Dubai, United Arab EmiratesTel +971
Naik PP
doaj
Evaluation of a neurotoxin as an adjunctive treatment modality for the management of gummy smile
Indian Dermatology Online Journal, 2019 Introduction: Excessive gingival display while smiling mars facial aesthetics, this condition is referred to as “gummy smile” (GS). Available literature suggests that Botulinum toxin type A (BTX-A) is effective in the management of excessive gingival ...
Neha Gupta, Sarvraj Kohli
doaj +1 more source
Evolution of Three-Finger Toxin Genes in Neotropical Colubrine Snakes (Colubridae)
Toxins, 2023 Snake venom research has historically focused on front-fanged species (Viperidae and Elapidae), limiting our knowledge of venom evolution in rear-fanged snakes across their ecologically diverse phylogeny.
Kristy Srodawa +3 more
doaj +1 more source
Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
Toxins, 2019 Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant and chemical poisonous compounds. Although a great effort has been made to understand their mode of action, some questions are still open.
B. Poulain, M. Popoff
semanticscholar +1 more source
Botulinum and Tetanus Neurotoxins [PDF]
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Dong, Min +2 more
openaire +3 more sources