Results 81 to 90 of about 65,558 (345)

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, EarlyView.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source

Defensin‐neurotoxin dyad in a basally branching metazoan sea anemone

The FEBS Journal, 2017
Recent studies suggest that vertebrate and invertebrate defensins have evolved from two independent ancestors, and that both defensins could share origins with animal toxins.
Chan-Hee Kim, Ye Jin Lee, Hye-Jin Go, H. Oh, Tae Kwan Lee, Ji Been Park, N. Park   +6 more
semanticscholar   +1 more source

A Flexible‐Substrate 5‐µm‐Diameter Needle Electrode: Minimizing Neuronal Death and Enabling Year‐Long Neural Recording

Advanced Materials Interfaces, EarlyView.
An electrophysiological recording technology that uses a 5‐µm‐diameter microneedle electrode device is presented. Due to the remarkable small dimension of the microneedle, the electrode provides minimal invasive neural recording in a mouse brain and enables long‐term recording exceeding the year‐long duration.
Hinata Sasaki, Koji Yamashita, Sayaki Shimizu, Kensei Sakamoto, Rika Numano, Kowa Koida, Takeshi Kawano   +6 more
wiley   +1 more source

Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products

Drugs in R&D, 2015
Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic indications and have revolutionized the field of aesthetic medicine so that they are the leading cosmetic procedure performed worldwide.
J. Frevert
semanticscholar   +1 more source

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

Advanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana, Samartha M C, Ashwath Acharya, Goutam Thakur, Manasa Nune, Vipul Agarwal   +5 more
wiley   +1 more source

Closed Genome Sequence of Chryseobacterium piperi Strain CTMT/ATCC BAA-1782, a Gram-Negative Bacterium with Clostridial Neurotoxin-Like Coding Sequences

Genome Announcements, 2017
Clostridial neurotoxins, including botulinum and tetanus neurotoxins, are among the deadliest known bacterial toxins. Until recently, the horizontal mobility of this toxin gene family appeared to be limited to the genus Clostridium.
T. Wentz, T. Muruvanda, S. Lomonaco, Nagarajan Thirunavukkarasu, M. Hoffmann, M. Allard, David R. Hodge, S. Pillai, T. Hammack, E. Brown, S. Sharma   +10 more
semanticscholar   +1 more source

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

Control of Autophagosome Axonal Retrograde Flux by Presynaptic Activity Unveiled Using Botulinum Neurotoxin Type A

Journal of Neuroscience, 2015
Botulinum neurotoxin type A (BoNT/A) is a highly potent neurotoxin that elicits flaccid paralysis by enzymatic cleavage of the exocytic machinery component SNAP25 in motor nerve terminals. However, recent evidence suggests that the neurotoxic activity of
Tong Wang, Sally Martin, A. Papadopulos, Callista B. Harper, T. Mavlyutov, D. Niranjan, N. Glass, J. Cooper-White, J. Sibarita, D. Choquet, B. Davletov, F. Meunier   +11 more
semanticscholar   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
This study demonstrated a tendency towards BBB permeability in APOEε4 participants emerging from mid‐age, with quantitative differences observable on a number of the measures. Results from this study may help identify at‐risk populations at an early stage which will be crucial in facilitating the development of early interventions to change the ...
Nourah M. Alruwais, Jenifer M. Rusted, Naji Tabet, Nicholas G. Dowell   +3 more
wiley   +1 more source