Results 81 to 90 of about 105,668 (383)
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells [PDF]
, 1989 Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern.
Ahnert-Hilger +25 more
core +1 more source
Botulinum neurotoxin formulations: overcoming the confusion
Clinical, Cosmetic and Investigational Dermatology, 2018 Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide.
Souphiyeh Samizadeh, K. De Boulle
semanticscholar +1 more source
Advanced Biology, EarlyView.A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso +5 more
wiley +1 more source
Contralateral Upper Limb Weakness Following Botulinum Toxin A Injection for Poststroke Spasticity
Acta Médica Portuguesa, 2020 Botulinum toxin type A has been approved for spasticity management in poststroke patients. The adverse effects are generally of two types: those related to local injection; and those related to the systemic effects from spread of the toxin ...
Alexandre Camões- Barbosa +2 more
doaj +1 more source
Breaking down the cellular responses to type I interferon neurotoxicity in the brain
Frontiers in Immunology, 2023 Since their original discovery, type I interferons (IFN-Is) have been closely associated with antiviral immune responses. However, their biological functions go far beyond this role, with balanced IFN-I activity being critical to maintain cellular and ...
Barney Viengkhou, Markus J. Hofer
doaj +1 more source
Effects of single and mixed infections with wild type and genetically modified Helicoverpa armigera nucleopolyhedrovirus on movement behaviour of cotton bollworm larvae [PDF]
, 2010 Naturally occurring insect viruses can modify the behaviour of infected insects and thereby modulate virus transmission. Modifications of the virus genome could alter these behavioural effects.
Cory, J.S. +5 more
core +2 more sources
Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy
Developmental Medicine & Child Neurology, 2018 To identify factors that increase the likelihood of systemic adverse events after botulinum neurotoxin A (BoNT‐A) injections in children with cerebral palsy (CP).
S. Paget +4 more
semanticscholar +1 more source
Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders
Advanced Functional Materials, EarlyView.This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao +5 more
wiley +1 more source
Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]
, 2013 • Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core