Results 1 to 10 of about 53,418 (337)
Frontiers in Aging Neuroscience, 2021 Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif +14 more
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Discovery of novel peptide neurotoxins from sea anemone species
Frontiers in Bioscience-Landmark, 2021 As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins. These peptides have been applied to neuroscience research tools or directly developed as marine drugs.
Jinxing Fu +3 more
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Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins
Marine Drugs, 2021 Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of
Rawan Mackieh +6 more
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Neurology and Therapy, 2023 Introduction Although acute and preventive treatments for migraine are commonly given in combination, data on the real-world effectiveness of ubrogepant as an acute treatment when used with an anti-calcitonin gene-related peptide (CGRP) monoclonal ...
Richard B. Lipton +7 more
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Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
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Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]
, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa +6 more
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Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism
Frontiers in Molecular Neuroscience, 2020 The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues +7 more
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Neurotoxicological Effects of Environmental and Occupational Agents
Türk Nöroloji Dergisi, 2022 There are numerous chemicals throughout the world, some of which have a dose- or exposure-related toxic effect. The effects of iatrogenic causes in particular can be better defined.
Rabia Gökçen Gözübatik Çelik +2 more
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Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications
Toxins, 2022 Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to receptors that are located in the pre- or post-synaptic membranes, thereby affecting physiological functions of synapses and affecting biological processes.
Kunming Zhou +4 more
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Toxins, 2021 Harmful effects caused by the exposure to paralytic shellfish toxins (PSTs) and bioactive extracellular compounds (BECs) on bivalves are frequently difficult to attribute to one or the other compound group. We evaluate and compare the distinct effects of
Virginia Angélica Bianchi +5 more
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