Discovery of novel peptide neurotoxins from sea anemone species
Frontiers in Bioscience, 2021 As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins. These peptides have been applied to neuroscience research tools or directly developed as marine drugs.
Bingmiao Gao
exaly +4 more sources
Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction [PDF]
Toxins, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (β-Bungarotoxin, β-Btx, from elapid snakes and α-Latrotoxin, α-Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in ...
Elisa Duregotti +6 more
doaj +11 more sources
Prediction of presynaptic and postsynaptic neurotoxins by combining various Chou’s pseudo components
Scientific Reports, 2017 Presynaptic and postsynaptic neurotoxins are two groups of neurotoxins. Identification of presynaptic and postsynaptic neurotoxins is an important work for numerous newly found toxins.
Yongchun Zuo, Lei Yang
exaly +3 more sources
Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications
Toxins, 2022 Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to receptors that are located in the pre- or post-synaptic membranes, thereby affecting physiological functions of synapses and affecting biological processes.
Kunming Zhou +4 more
doaj +2 more sources
Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins
International Journal of Molecular Sciences, 2021 Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new research ...
Kevin Smith, Nafissa Ismail, Rongji Dai
exaly +2 more sources
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals [PDF]
Cellular Microbiology, 2016 Botulinum and tetanus neurotoxins are the most toxic substances known and form the growing family of clostridial neurotoxins. They are composed of a metalloprotease light chain (L), linked via a disulfide bond to a heavy chain (H). H mediates the binding
AZARNIA TEHRAN, Domenico +7 more
core +2 more sources
Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology
Pharmacological Reviews, 2017 The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown.
Marco Pirazzini +2 more
exaly +2 more sources
Use of Cosmetics in Pregnancy and Neurotoxicity: Can It Increase the Risk of Congenital Enteric Neuropathies? [PDF]
BiomoleculesPregnancy is a particularly vulnerable period for the growing fetus, when exposure to toxic agents, especially in the early phases, can decisively harm embryo development and compromise the future health of the newborn.
Kendra Jones +3 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2021 Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif +14 more
doaj +1 more source
What Are the Neurotoxins in Hemotoxic Snake Venoms?
International Journal of Molecular Sciences, 2023 Snake venoms as tools for hunting are primarily aimed at the most vital systems of the prey, especially the nervous and circulatory systems. In general, snakes of the Elapidae family produce neurotoxic venoms comprising of toxins targeting the nervous ...
A. Osipov, Y. Utkin
semanticscholar +1 more source