Results 101 to 110 of about 53,418 (337)

Do repetitive botulinum neurotoxin injections induce muscle fibrosis? Sonographic observation of the masseter muscle [PDF]

, 2023
Hyeon‐Jung Koo, Hyewon Hu, Woo‐Ram Kim, Ji‐Soo Kim, Hee‐Jin Kim, Kyu‐Ho Yi   +5 more
openalex   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Paraklooramfetamiini mõju psühhomotoorsele aktiivsusele ja serotoniini ja dopamiini tasemetele septumis ja prefrontaalkorteksis erineva püsisotsiaalsusega loomadel [PDF]

, 2018
Social behaviour plays important role in many psychopathologies. Sociability has been shown to be a stable trait in animals and individual differences in sociability are related to 5-HT transmission in septum and prefrontal cortex. The aim of the current
Kastein, Gisela
core  

The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel [PDF]

, 1997
Jamie I. Fletcher, Bogdan E. Chapman, Joel P. Mackay, M.E.H. Howden, Glenn F. King   +4 more
openalex   +1 more source

Public health interventions to minimize the role of occupational exposure in the development of Parkinson’s disease

Annals of Movement Disorders
Parkinson’s disease (PD) is a progressive neurodegenerative condition that significantly impairs the quality of life of affected individuals. This study aims to identify occupational risk factors for PD, examine their implications, and propose preventive
Saurabh RamBihariLal Shrivastava, Prateek Sudhakar Bobhate, Bayu Fajar Pratama, Yugeshwari R. Tiwade   +3 more
doaj   +1 more source

Inhibition of Membrane Na+ Channels by A Type Botulinum Toxin at Femtomolar Concentrations in Central and Peripheral Neurons

Journal of Pharmacological Sciences, 2012
Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons.
Min-Chul Shin, Masahito Wakita, Du-Jie Xie, Toshitaka Yamaga, Satomi Iwata, Yasushi Torii, Tetsuhiro Harakawa, Akihiro Ginnaga, Shunji Kozaki, Norio Akaike   +9 more
doaj   +1 more source

Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins [PDF]

, 2003
Rudi D’Hooge, Gerda Van de Vijver, Pierre‐Paul van Bogaert, Bart Marescau, Raymond Vanholder, Peter Paul De Deyn   +5 more
openalex   +1 more source