Results 91 to 100 of about 7,882 (239)
Clostridial Neurotoxins: Mechanism of Action of Tetanus and Botulinum Neurotoxins
, 2004 Tetanus and botulinum neurotoxins are the most potent toxins known as few nanograms are sufficient to kill most mammals. Their exceptional toxicity derives from: a) the absolute specificity for the nervous tissue, whose complete functionality is ...
MONTECUCCO, CESARE, ROSSETTO, ORNELLA
core
Mode of action of botulinum and tetanus neurotoxins [PDF]
, 2004 Clostridium botulinum and Clostridium tetani synthesize botulinum neurotoxins (A to G) and the tetanus toxin, which are responsible for botulism and tetanus, respectively.
POPOFF, Michel-Robert +2 more
core +1 more source
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
NEUROTOX: A UNIQUE DATABASE FOR ANIMAL NEUROTOXINS [PDF]
, 2015 Objective: A wide range of toxic effects against other species are affected through potential protein molecules called neurotoxins. Among various kinds of toxins, neurotoxins play a critical role in life of other organisms (especially humans).
Kumar, R. Barani, Suresh, M. Xavier
core +1 more source
Therapeutic applications of botulinum neurotoxins in head and neck disorders [PDF]
, 2015 ObjectiveThe aim of this article is to review the mechanism of action, physiological effects, and therapeutic applications of botulinum neurotoxins in the head and neck area.Study designAn extensive literature search was performed using keywords.
Alshadwi, Ahmad +5 more
core +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source
Botulinum Neurotoxins (BoNTs)—Antibody and Vaccine [PDF]
, 2018 Botulism, caused by exposure to one or more of the eight serotypes of botulinum neurotoxins (BoNTs) (BoNT/A through H), is often fatal without rapid treatment.
James D. Marks +4 more
core +1 more source
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source