Results 71 to 80 of about 43,184 (300)

Prediction of presynaptic and postsynaptic neurotoxins by combining various Chou’s pseudo components

open access: yesScientific Reports, 2017
Presynaptic and postsynaptic neurotoxins are two groups of neurotoxins. Identification of presynaptic and postsynaptic neurotoxins is an important work for numerous newly found toxins.
Haiyan Huo   +5 more
doaj   +1 more source

The impact of fruit flavonoids on memory and cognition [PDF]

open access: yes, 2010
There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline.
Bhat   +10 more
core   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

open access: yesAdvanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo   +6 more
wiley   +1 more source

Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins

open access: yesToxins, 2015
Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but ...
Sara M. Schaefer   +2 more
doaj   +1 more source

Behavioural analysis of web building anomalies in the orb-weaving spider Zygiella x-notata (Araneae, Araneidae) [PDF]

open access: yes, 2012
Among animal constructions, spider’s orb webs represent regular geometrical architecture models. Their construction is the result of successive, simple and reproducible behavioural patterns, often considered as stereotyped.
Leborgne, Raymond   +2 more
core   +2 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

open access: yesAdvanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi   +2 more
wiley   +1 more source

Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

open access: yesToxins, 2014
In Brazil, Tityus serrulatus (Ts) is the species responsible for most of the scorpion related accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) present high interest, due to their effect in the envenoming process ...
Felipe A. Cerni   +6 more
doaj   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim   +4 more
wiley   +1 more source

Public health interventions to minimize the role of occupational exposure in the development of Parkinson’s disease

open access: yesAnnals of Movement Disorders
Parkinson’s disease (PD) is a progressive neurodegenerative condition that significantly impairs the quality of life of affected individuals. This study aims to identify occupational risk factors for PD, examine their implications, and propose preventive
Saurabh RamBihariLal Shrivastava   +3 more
doaj   +1 more source

Neurotoxin Merging: A Strategy Deployed by the Venom of the Spider Cupiennius salei to Potentiate Toxicity on Insects

open access: yesToxins, 2020
The venom of Cupiennius salei is composed of dozens of neurotoxins, with most of them supposed to act on ion channels. Some insecticidal monomeric neurotoxins contain an α-helical part besides their inhibitor cystine knot (ICK) motif (type 1).
Benjamin Clémençon   +7 more
doaj   +1 more source

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