Results 61 to 70 of about 21,263 (262)

Public health interventions to minimize the role of occupational exposure in the development of Parkinson’s disease

Annals of Movement Disorders
Parkinson’s disease (PD) is a progressive neurodegenerative condition that significantly impairs the quality of life of affected individuals. This study aims to identify occupational risk factors for PD, examine their implications, and propose preventive
Saurabh RamBihariLal Shrivastava, Prateek Sudhakar Bobhate, Bayu Fajar Pratama, Yugeshwari R. Tiwade   +3 more
doaj   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

Toxins, 2017
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which ...
Michael W. Peck, Theresa J. Smith, Fabrizio Anniballi, John W. Austin, Luca Bano, Marite Bradshaw, Paula Cuervo, Luisa W. Cheng, Yagmur Derman, Brigitte G. Dorner, Audrey Fisher, Karen K. Hill, Suzanne R. Kalb, Hannu Korkeala, Miia Lindström, Florigio Lista, Carolina Lúquez, Christelle Mazuet, Marco Pirazzini, Michel R. Popoff, Ornella Rossetto, Andreas Rummel, Dorothea Sesardic, Bal Ram Singh, Sandra C. Stringer   +24 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Biochemical and Electrophysiological Characterization of Two Sea Anemone Type 1 Potassium Toxins from a Geographically Distant Population of Bunodosoma caissarum

Marine Drugs, 2013
Sea anemone (Cnidaria, Anthozoa) venom is an important source of bioactive compounds used as tools to study the pharmacology and structure-function of voltage-gated K+ channels (KV).
André J. Zaharenko, Jan Tytgat, José C. Freitas, Adriano M. C. Pimenta, José E. P. W. Bicudo, Gabriela G. Montandon, Juliana S. Cassoli, Bruno Madio, Diego J. B. Orts, Steve Peigneur   +9 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Haemorrhagic, proteolytic and neurotoxic activities produced by Duvernoy”™s gland secretion from the false coral snake (Erythrolamprus bizona Jan 1863) (Serpentes: Colubridae)

Revista Científica, 2010
Many colubrid snakes produce toxic oral secretions. Venom (Duvernoy´s gland secretion) collected from Venezuelan species of opisthoglyphous (rear-fanged) colubrid snakes has been studied.
Karel Lemoine, Alexis Rodríguez Acosta
doaj  

The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research

Marine Drugs, 2018
Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops.
Aldo Nicosia, Alexander Mikov, Matteo Cammarata, Paolo Colombo, Yaroslav Andreev, Sergey Kozlov, Angela Cuttitta   +6 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source