Results 81 to 90 of about 54,476 (302)

Biochemical and Electrophysiological Characterization of Two Sea Anemone Type 1 Potassium Toxins from a Geographically Distant Population of Bunodosoma caissarum

Marine Drugs, 2013
Sea anemone (Cnidaria, Anthozoa) venom is an important source of bioactive compounds used as tools to study the pharmacology and structure-function of voltage-gated K+ channels (KV).
André J. Zaharenko, Jan Tytgat, José C. Freitas, Adriano M. C. Pimenta, José E. P. W. Bicudo, Gabriela G. Montandon, Juliana S. Cassoli, Bruno Madio, Diego J. B. Orts, Steve Peigneur   +9 more
doaj   +1 more source

Current Status and Future Directions of Botulinum Neurotoxins for Targeting Pain Processing

Toxins, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
S. Pellett, T. Yaksh, R. Ramachandran
semanticscholar   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research

Marine Drugs, 2018
Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops.
Aldo Nicosia, Alexander Mikov, Matteo Cammarata, Paolo Colombo, Yaroslav Andreev, Sergey Kozlov, Angela Cuttitta   +6 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Haemorrhagic, proteolytic and neurotoxic activities produced by Duvernoy”™s gland secretion from the false coral snake (Erythrolamprus bizona Jan 1863) (Serpentes: Colubridae)

Revista Científica, 2010
Many colubrid snakes produce toxic oral secretions. Venom (Duvernoy´s gland secretion) collected from Venezuelan species of opisthoglyphous (rear-fanged) colubrid snakes has been studied.
Karel Lemoine, Alexis Rodríguez Acosta
doaj  

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins

Scientific Reports, 2015
Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors targeting common steps of their intoxication process.
Domenico Azarnia Tehran, G. Zanetti, O. Leka, F. Lista, S. Fillo, T. Binz, C. Shone, O. Rossetto, C. Montecucco, C. Paradisi, Andrea Mattarei, M. Pirazzini   +11 more
semanticscholar   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Cell Reports, 2014
Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol.
M. Pirazzini, Domenico Azarnia Tehran, G. Zanetti, A. Megighian, M. Scorzeto, S. Fillo, C. Shone, T. Binz, O. Rossetto, F. Lista, C. Montecucco   +10 more
semanticscholar   +1 more source