Results 11 to 20 of about 77,752 (388)
Botulinum and Tetanus Neurotoxins. [PDF]
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins.
M. Dong, G. Masuyer, P. Stenmark
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On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this
Cesare Montecucco, Maria Berica Rasotto
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Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
Archives of Toxicology, 2022 Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the release of ...
M. Pirazzini, C. Montecucco, O. Rossetto
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Neurology and Therapy, 2023 Introduction Although acute and preventive treatments for migraine are commonly given in combination, data on the real-world effectiveness of ubrogepant as an acute treatment when used with an anti-calcitonin gene-related peptide (CGRP) monoclonal ...
Richard B. Lipton +7 more
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Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins
Marine Drugs, 2021 Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of
Rawan Mackieh +6 more
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Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
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Neurotoxicological Effects of Environmental and Occupational Agents
Türk Nöroloji Dergisi, 2022 There are numerous chemicals throughout the world, some of which have a dose- or exposure-related toxic effect. The effects of iatrogenic causes in particular can be better defined.
Rabia Gökçen Gözübatik Çelik +2 more
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Journal of Neurology, Neurosurgery & Psychiatry, 2004 The genus Clostridium comprises a number of spore forming Gram positive, rod shaped bacilli. They are found in the intestines of numerous mammalian species including domestic animals, horses, chickens, and humans. They are also widely distributed in the soil and in marine and freshwater sediments.
Goonetilleke A, Harris JB
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Proceedings of the National Academy of Sciences of the United States of America, 1998 Abeta1-42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role in Alzheimer's pathogenesis. Neurotoxicity of amyloid beta protein (Abeta) has been attributed to its fibrillar forms, but experiments presented here ...
M. Lambert +14 more
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The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
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