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Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins
International Journal of Molecular Sciences, 2021 Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new ...
Nafissa Ismail +2 more
exaly +2 more sources
Antipruritic Effects of Botulinum Neurotoxins [PDF]
Toxins, 2018 This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and ...
Parisa Gazerani, Gazerani Parisa
exaly +2 more sources
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Toxicon, 2013
α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmission.
Geoffrey K Isbister, Wayne C Hodgson
exaly +3 more sources
α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmission.
Geoffrey K Isbister, Wayne C Hodgson
exaly +3 more sources
Presynaptic enzymatic neurotoxins
Journal of Neurochemistry, 2006 Botulinum neurotoxins produced by anaerobic bacteria of the genus Clostridium are the most toxic proteins known, with mouse LD50 values in the 1-5 ng/kg range, and are solely responsible for the pathophysiology of botulism.
Ornella Rossetto +2 more
exaly +2 more sources
Facial Plastic Surgery, 2019
AbstractBotulinum toxin is integral to the practice of facial plastic surgery. Since it was approved by the U.S. Food and Drug Administration for the temporary improvement of glabellar rhytids in 2002, botulinum toxin has achieved a growing number of off-label clinical applications. These include the management of facial rhytids, brow ptosis, excessive
Adrian A. Ong, David A. Sherris
openaire +2 more sources
AbstractBotulinum toxin is integral to the practice of facial plastic surgery. Since it was approved by the U.S. Food and Drug Administration for the temporary improvement of glabellar rhytids in 2002, botulinum toxin has achieved a growing number of off-label clinical applications. These include the management of facial rhytids, brow ptosis, excessive
Adrian A. Ong, David A. Sherris
openaire +2 more sources