Results 21 to 30 of about 377,603 (266)

Taurine ameliorates volatile organic compounds-induced cognitive impairment in young rats via suppressing oxidative stress, regulating neurotransmitter and activating NMDA receptor

Frontiers in Veterinary Science, 2022
Long-term exposure to volatile organic compounds (VOCs) in children leads to intellectual and cognitive impairment. Taurine is an essential nutritional amino acid for children, which can improve neurological development in children.
Yongchao Gao, Chao Sun, Ting Gao, Zhiyong Liu, Zhao Yang, Hui Deng, Peng Fan, Junhong Gao   +7 more
doaj   +1 more source

Emerging roles of keratinocytes in nociceptive transduction and regulation

Frontiers in Molecular Neuroscience, 2022
Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence has elucidated the roles of keratinocytes in a wide range of pathophysiological processes including cutaneous nociception, pruritus, and inflammation ...
Xiaohan Xu, Catherine Yu, Catherine Yu, Catherine Yu, Li Xu, Jijun Xu, Jijun Xu, Jijun Xu   +7 more
doaj   +1 more source

Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level

Frontiers in Neuroscience, 2020
There is increasing evidence suggesting a link between the autism spectrum disorder (ASD) and the gastrointestinal (GI) microbiome. Experimental and clinical studies have shown that patients diagnosed with ASD display alterations of the gut microbiota ...
Enriqueta Garcia-Gutierrez, Arjan Narbad, Juan Miguel Rodríguez   +2 more
doaj   +1 more source

Developmental Neurotransmitters? [PDF]

Neuron, 2002
Previous studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype is absent in embryonic mice that lack vesicular release. Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca(2+) entry, or ...
Owens, David F., Kriegstein, Arnold R.
openaire   +2 more sources

Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure

Noise and Health
The developing brain is significantly affected by long-term exposure to noise at an early age, leading to functional disorders such as learning and memory impairments.
Lin Wu, Ying Liu, Hu Zhou, Zhenzhen Cao, Jianyun Yu   +4 more
doaj   +1 more source

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

Frontiers in Neuroscience, 2018
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain and peripheral tissues, methods and results for DMT ...
Steven A. Barker
doaj   +1 more source

Tryptophan and Cortisol Modulate the Kynurenine and Serotonin Transcriptional Pathway in the Kidney of Oncorhynchus kisutch

Animals, 2023
Aquaculture fish are kept for long periods in sea cages or tanks. Consequently, accumulated stress causes the fish to present serious problems with critical economic losses.
Luis Vargas-Chacoff, Daniela Nualart, Carolina Vargas-Lagos, Francisco Dann, José Luis Muñoz, Juan Pablo Pontigo   +5 more
doaj   +1 more source

Unveiling the Neural Environment in Cancer: Exploring the Role of Neural Circuit Players and Potential Therapeutic Strategies

Cells, 2023
The regulation of the immune environment within the tumor microenvironment has provided new opportunities for cancer treatment. However, an important microenvironment surrounding cancer that is often overlooked despite its significance in cancer ...
Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Jung-Hye Choi, Chang-Hoon Lee   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target

Molecules
Gamma-glutamate is an important excitatory neurotransmitter in the central nervous system (CNS), which plays an important role in transmitting synapses, plasticity, and other brain activities.
Nidhi Puranik, Minseok Song
doaj   +1 more source