Results 41 to 50 of about 415,134 (313)

Adsorption Kinetic Model Predicts and Improves Reliability of Electrochemical Serotonin Detection

Methods and Protocols, 2023
Serotonin (5-HT) is a neurotransmitter involved in many biophysiological processes in the brain and in the gastrointestinal tract. Electrochemical methods are commonly used to quantify 5-HT, but their reliability may suffer due to the time-dependent ...
Ashley Augustiny Chapin, Jinjing Han, Reza Ghodssi   +2 more
doaj   +1 more source

Neurotransmitter release [PDF]

FEBS Letters, 1990
Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron‐lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron‐dense granules store and release proteins and peptides.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Acetate and propionate vs. iTBS as a novel method for cognitive dysfunction and anxiety symptoms in delayed encephalopathy after acute carbon monoxide poisoning rat

Frontiers in Pharmacology
BackgroundThe optimal treatment methods for delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) were not identified. Thus, this study was conducted to compare the efficacies of intermittent theta burst stimulation (iTBS) and short ...
Tianyu Meng, Xin Zhang, Jili Zhao, Hui Xue, Lehua Yu   +4 more
doaj   +1 more source

Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca2+ signaling

eLife, 2015
The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal ...
Tarjani Agrawal, Gaiti Hasan
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Innovative strategies for post-stroke depression: integrating traditional Chinese medicine with neurobiological insights, including the gut-brain axis

Frontiers in Pharmacology
Post-stroke depression (PSD) is a debilitating condition affecting more than one-third of stroke survivors, leading to significant impairments in mood, cognitive function, and overall quality of life.
Lin Zhu, Lin Zhu, Ruina Han, Linxia He, Bingfa Pan, Weijie Zhong, Yi Li, Xinru Liu   +7 more
doaj   +1 more source

Striatonigrostriatal Spirals in Addiction

Frontiers in Neural Circuits, 2021
A biological reward system is integral to all animal life and humans are no exception. For millennia individuals have investigated this system and its influences on human behavior.
Andy Sivils, John Q. Wang, Xiang-Ping Chu   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels

Neural Regeneration Research
Epilepsy, a common neurological disorder, is characterized by recurrent seizures that can lead to cognitive, psychological, and neurobiological consequences.
Xueqing Du, Yi Wang, Xuefeng Wang, Xin Tian, Wei Jing   +4 more
doaj   +1 more source