Results 41 to 50 of about 60,284 (256)

Adsorption Kinetic Model Predicts and Improves Reliability of Electrochemical Serotonin Detection

Methods and Protocols, 2023
Serotonin (5-HT) is a neurotransmitter involved in many biophysiological processes in the brain and in the gastrointestinal tract. Electrochemical methods are commonly used to quantify 5-HT, but their reliability may suffer due to the time-dependent ...
Ashley Augustiny Chapin, Jinjing Han, Reza Ghodssi   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Acetate and propionate vs. iTBS as a novel method for cognitive dysfunction and anxiety symptoms in delayed encephalopathy after acute carbon monoxide poisoning rat

Frontiers in Pharmacology
BackgroundThe optimal treatment methods for delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) were not identified. Thus, this study was conducted to compare the efficacies of intermittent theta burst stimulation (iTBS) and short ...
Tianyu Meng, Xin Zhang, Jili Zhao, Hui Xue, Lehua Yu   +4 more
doaj   +1 more source

Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca2+ signaling

eLife, 2015
The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal ...
Tarjani Agrawal, Gaiti Hasan
doaj   +1 more source

Neurotransmitter release [PDF]

FEBS Letters, 1990
Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron‐lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron‐dense granules store and release proteins and peptides.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Innovative strategies for post-stroke depression: integrating traditional Chinese medicine with neurobiological insights, including the gut-brain axis

Frontiers in Pharmacology
Post-stroke depression (PSD) is a debilitating condition affecting more than one-third of stroke survivors, leading to significant impairments in mood, cognitive function, and overall quality of life.
Lin Zhu, Lin Zhu, Ruina Han, Linxia He, Bingfa Pan, Weijie Zhong, Yi Li, Xinru Liu   +7 more
doaj   +1 more source

Striatonigrostriatal Spirals in Addiction

Frontiers in Neural Circuits, 2021
A biological reward system is integral to all animal life and humans are no exception. For millennia individuals have investigated this system and its influences on human behavior.
Andy Sivils, John Q. Wang, Xiang-Ping Chu   +2 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels

Neural Regeneration Research
Epilepsy, a common neurological disorder, is characterized by recurrent seizures that can lead to cognitive, psychological, and neurobiological consequences.
Xueqing Du, Yi Wang, Xuefeng Wang, Xin Tian, Wei Jing   +4 more
doaj   +1 more source