Results 51 to 60 of about 470,740 (429)
Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease [PDF]
, 2009 Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals.
Ara jo +44 more
core +2 more sources
Neurotransmitter receptors on microglia
Stroke and vascular neurology, 2016 As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity.
Huan Liu, R. Leak, Xiaoming Hu
semanticscholar +1 more source
Biomedicines, 2023 Breast cancer is frequently the most diagnosed female cancer in the world. The experimental studies on cancer seldom focus on the relationship between the central nervous system and cancer.
Gloria M. Calaf +4 more
doaj +1 more source
Membrane bridging by Munc13-1 is crucial for neurotransmitter release
eLife, 2019 Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions ...
B. Quade +9 more
semanticscholar +1 more source
A Life of Neurotransmitters [PDF]
Annual Review of Pharmacology and Toxicology, 2017 Development of scientific creativity is often tied closely to mentorship. In my case, two years with Julius Axelrod, the sum total of my research training, was transformative. My mentoring generations of graduate students and postdoctoral fellows has been as nurturing for me as it has been for them.
openaire +3 more sources
Glassy Carbon Microelectrode Arrays Enable Voltage-Peak Separated Simultaneous Detection of Dopamine and Serotonin Using Fast Scan Cyclic Voltammetry [PDF]
, 2020 Progress in real-time, simultaneous in vivo detection of multiple neurotransmitters will help accelerate advances in neuroscience research. The need for development of probes capable of stable electrochemical detection of rapid neurotransmitter fluctuations with high sensitivity and selectivity and sub-second temporal resolution has, therefore, become ...
arxiv +1 more source
Mechanism of neurotransmitter release coming into focus
Protein Science, 2018 Research for three decades and major recent advances have provided crucial insights into how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading to reconstitution of basic steps that underlie Ca2+‐dependent membrane ...
J. Rizo
semanticscholar +1 more source
Frontiers in Neuroscience, 2018 This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain and peripheral tissues, methods and results for DMT ...
Steven A. Barker
doaj +1 more source
Insights into the leveraging of GABAergic signaling in cancer therapy
Cancer Medicine, 2023 Gamma‐aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain of adult mammals. Several studies have demonstrated that the GABAergic system may regulate tumor development via GABA receptors, downstream cyclic adenosine monophosphate
Tian‐Jiao Li +3 more
doaj +1 more source
Frontiers in Neurology, 2023 ObjectiveThe present study aimed to explore the correlation of serum total folic acid concentration with severe difficulty falling asleep among US adults.MethodsCross-sectional data were collected from the National Health and Nutrition Examination Survey
Haoyu An, Qiyun Xue, Jingyi Zhang
doaj +1 more source