Results 51 to 60 of about 549,266 (339)
Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]
, 2006 Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber +32 more
core +6 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
Microbial BiotechnologyThe ubiquitous pathogen Pseudomonas aeruginosa is attracted to γ‐aminobutyrate (GABA), acetylcholine, histamine, serotonin, epinephrine, norepinephrine, dopamine, tyramine, glycine, and glutamate via chemotaxis.
Elizabet Monteagudo‐Cascales +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2018 Serotonin or 5-hydroxytryptamine (5-HT) is an important neurotransmitter that is found in mammalian taste buds and can regulate the output of intragemmal signaling networks onto afferent nerve fibers.
Hong-Ru Pan +8 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Tinnitus and stress – from bedside to bench and back
Frontiers in Systems Neuroscience, 2012 The aim of this review is to focus the attention of clinicians and basic researchers on the association between emotional stress and tinnitus. Although tinnitus is an auditory symptom, its onset and progression often associates with emotional strain ...
Birgit eMazurek +3 more
doaj +1 more source
Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]
, 2013 Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C. +4 more
core +2 more sources
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Efficacy and mechanisms of action of Shangxia Liangji formula in the treatment of insomnia
Sleep ResearchAims Shangxia Liangji formula (SXLJF) is a traditional Chinese medicine formula used clinically for the treatment of insomnia. However, the exact mechanism of SXLJF remains unclear.
Feng‐Ling Xiao +7 more
doaj +1 more source